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Title: Role of the Nucleus Incertus in Cognition
Authors: WU YOU
Keywords: Nucleus Incertus, stress, cognition, prefrontal cortex, chemoarchitecture, HP-mPFC LTP, behavior
Issue Date: 14-Jul-2014
Citation: WU YOU (2014-07-14). Role of the Nucleus Incertus in Cognition. ScholarBank@NUS Repository.
Abstract: Stress is an important modulator of cognition. Recent evidence suggests that the nucleus incertus (NI) plays a potential role in stress and cognition modulation. In this thesis, to test the hypothesis that the NI plays a critical role in cognition under stress, especially in PFC modulation: (1) The chemoarchitecture of NI neurons projecting to mPFC and ACC was characterized, demonstrating the high expression levels of CRF1 receptor, RLN3 and dopamine D2S in NI-PFC projection neurons; (2) The role of the NI in stressor-induced HP-mPFC LTP modulation was validated by the rescue effects of intra-NI CRF1 antagonist treatment on HP-mPFC LTP suppression caused by elevation stress; (3) The role of the NI in stress-induced mPFC working memory behavior modulation was also studied by delayed spatial win-shift task. All results strongly suggested the critical role of NI in PFC modulation under stress.
Appears in Collections:Master's Theses (Open)

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