Please use this identifier to cite or link to this item: https://doi.org/10.1529/biophysj.103.034991
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dc.titleImaging cells and tissues with refractive index radiology
dc.contributor.authorHwu, Y.
dc.contributor.authorTsai, W.L.
dc.contributor.authorChang, H.M.
dc.contributor.authorYeh, H.I.
dc.contributor.authorHsu, P.C.
dc.contributor.authorYang, Y.C.
dc.contributor.authorSu, Y.T.
dc.contributor.authorTsai, H.L.
dc.contributor.authorChow, G.M.
dc.contributor.authorHo, P.C.
dc.contributor.authorLi, S.C.
dc.contributor.authorMoser, H.O.
dc.contributor.authorYang, P.
dc.contributor.authorSeol, S.K.
dc.contributor.authorKim, C.C.
dc.contributor.authorJe, J.H.
dc.contributor.authorStefanekova, E.
dc.contributor.authorGroso, A.
dc.contributor.authorMargaritondo, G.
dc.date.accessioned2014-11-28T08:43:20Z
dc.date.available2014-11-28T08:43:20Z
dc.date.issued2004-12
dc.identifier.citationHwu, Y., Tsai, W.L., Chang, H.M., Yeh, H.I., Hsu, P.C., Yang, Y.C., Su, Y.T., Tsai, H.L., Chow, G.M., Ho, P.C., Li, S.C., Moser, H.O., Yang, P., Seol, S.K., Kim, C.C., Je, J.H., Stefanekova, E., Groso, A., Margaritondo, G. (2004-12). Imaging cells and tissues with refractive index radiology. Biophysical Journal 87 (6) : 4180-4187. ScholarBank@NUS Repository. https://doi.org/10.1529/biophysj.103.034991
dc.identifier.issn00063495
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/113021
dc.description.abstractCan individual cells, including live cells, be imaged using hard x rays? Common wisdom until now required sophisticated staining techniques for this task. We show instead that individual cells and cell details can be detected in culture solution and tissues with no staining and no other contrast-enhancing preparation. The sample examined can be much thicker than for many other microscopy techniques without sacrificing the capability to resolve cells. The key factor in our approach is the use of a coherent synchrotron source and of contrast mechanisms based on the refractive index. The first successful tests were conducted on a variety of cell systems including skin and internal leaf cells, mouse neurons, rabbit fibroblast cells, and human tumor cells.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1529/biophysj.103.034991
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentPHARMACY
dc.contributor.departmentSINGAPORE SYNCHROTRON LIGHT SOURCE
dc.contributor.departmentMATERIALS SCIENCE
dc.description.doi10.1529/biophysj.103.034991
dc.description.sourcetitleBiophysical Journal
dc.description.volume87
dc.description.issue6
dc.description.page4180-4187
dc.description.codenBIOJA
dc.identifier.isiut000225426700053
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