Please use this identifier to cite or link to this item:
https://doi.org/10.1023/A:1027399707418
DC Field | Value | |
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dc.title | Dose-Dependent Effect of Aprotinin on Aggravated Pro-Inflammatory Cytokines in Patients with Pulmonary Hypertension Following Cardiopulmonary Bypass | |
dc.contributor.author | Lei, Y. | |
dc.contributor.author | Haider, H.Kh. | |
dc.contributor.author | Chusnsheng, W. | |
dc.contributor.author | Zhiqiang, C. | |
dc.contributor.author | Hao, C. | |
dc.contributor.author | Kejian, H. | |
dc.contributor.author | Qiang, Z. | |
dc.date.accessioned | 2014-11-28T07:56:48Z | |
dc.date.available | 2014-11-28T07:56:48Z | |
dc.date.issued | 2003 | |
dc.identifier.citation | Lei, Y., Haider, H.Kh., Chusnsheng, W., Zhiqiang, C., Hao, C., Kejian, H., Qiang, Z. (2003). Dose-Dependent Effect of Aprotinin on Aggravated Pro-Inflammatory Cytokines in Patients with Pulmonary Hypertension Following Cardiopulmonary Bypass. Cardiovascular Drugs and Therapy 17 (4) : 343-348. ScholarBank@NUS Repository. https://doi.org/10.1023/A:1027399707418 | |
dc.identifier.issn | 09203206 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/112788 | |
dc.description.abstract | Background: To investigate the dose dependent effect of aprotinin on aggravated pro-inflammatory cytokines in patients with pulmonary hypertension (PH) after cardiopulmonary bypass (CPB). Methods: Thirty-two patients with pulmonary arterial pressure (PAP) above 60 mmHg were recruited. They were assigned randomly to control (Group A, n = 8), and treated groups (Group B with aprotinin = 0.5 × 105 KIU/Kg, and Group C with aprotinin = 1.0 × 105 KIU/Kg, n = 12 each group). Blood samples were collected at various intervals of time and analyzed, from "0" hour (before CPB as baseline), at the completion of CPB, 4 hours and 24 hours after CPB, to measure the concentrations of interleukin 1β (IL-1β), interleukin-8 (IL-8), interleukin-10 (IL-10) and tumor necrosis factor-α (TNF-α). Results: All the biomarkers significantly increased after CPB. There was no significant difference in cytokine levels between Group A and group B after CPB. But IL-1β, IL-8 and TNF-α of Group C were not only significantly lower than Group A (p < 0.05), but also lower than Group B at various time points after CPB (p < 0.05). IL-10 of group C was significantly higher than Group A and Group B after CPB (p < 0.05). Conclusions: High dose aprotinin can suppress the release of pro-inflammatory cytokines IL-1β, IL-8 and TNF-α, and enhance the release of IL-10 in patients with PH after CPB. For patients having PH, there exists a simple and potential way to reduce the inflammatory response by applying high dose aprotinin. | |
dc.description.uri | http://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1023/A:1027399707418 | |
dc.source | Scopus | |
dc.subject | Cardiopulmonary bypass | |
dc.subject | Cytokine | |
dc.subject | Inflammatory response | |
dc.subject | Pulmonary hypertension | |
dc.type | Article | |
dc.contributor.department | NATIONAL UNIVERSITY MEDICAL INSTITUTES | |
dc.description.doi | 10.1023/A:1027399707418 | |
dc.description.sourcetitle | Cardiovascular Drugs and Therapy | |
dc.description.volume | 17 | |
dc.description.issue | 4 | |
dc.description.page | 343-348 | |
dc.description.coden | CDTHE | |
dc.identifier.isiut | 000186409000006 | |
Appears in Collections: | Staff Publications |
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