Please use this identifier to cite or link to this item: https://doi.org/10.1023/A:1027399707418
Title: Dose-Dependent Effect of Aprotinin on Aggravated Pro-Inflammatory Cytokines in Patients with Pulmonary Hypertension Following Cardiopulmonary Bypass
Authors: Lei, Y.
Haider, H.Kh. 
Chusnsheng, W.
Zhiqiang, C.
Hao, C.
Kejian, H.
Qiang, Z.
Keywords: Cardiopulmonary bypass
Cytokine
Inflammatory response
Pulmonary hypertension
Issue Date: 2003
Citation: Lei, Y., Haider, H.Kh., Chusnsheng, W., Zhiqiang, C., Hao, C., Kejian, H., Qiang, Z. (2003). Dose-Dependent Effect of Aprotinin on Aggravated Pro-Inflammatory Cytokines in Patients with Pulmonary Hypertension Following Cardiopulmonary Bypass. Cardiovascular Drugs and Therapy 17 (4) : 343-348. ScholarBank@NUS Repository. https://doi.org/10.1023/A:1027399707418
Abstract: Background: To investigate the dose dependent effect of aprotinin on aggravated pro-inflammatory cytokines in patients with pulmonary hypertension (PH) after cardiopulmonary bypass (CPB). Methods: Thirty-two patients with pulmonary arterial pressure (PAP) above 60 mmHg were recruited. They were assigned randomly to control (Group A, n = 8), and treated groups (Group B with aprotinin = 0.5 × 105 KIU/Kg, and Group C with aprotinin = 1.0 × 105 KIU/Kg, n = 12 each group). Blood samples were collected at various intervals of time and analyzed, from "0" hour (before CPB as baseline), at the completion of CPB, 4 hours and 24 hours after CPB, to measure the concentrations of interleukin 1β (IL-1β), interleukin-8 (IL-8), interleukin-10 (IL-10) and tumor necrosis factor-α (TNF-α). Results: All the biomarkers significantly increased after CPB. There was no significant difference in cytokine levels between Group A and group B after CPB. But IL-1β, IL-8 and TNF-α of Group C were not only significantly lower than Group A (p < 0.05), but also lower than Group B at various time points after CPB (p < 0.05). IL-10 of group C was significantly higher than Group A and Group B after CPB (p < 0.05). Conclusions: High dose aprotinin can suppress the release of pro-inflammatory cytokines IL-1β, IL-8 and TNF-α, and enhance the release of IL-10 in patients with PH after CPB. For patients having PH, there exists a simple and potential way to reduce the inflammatory response by applying high dose aprotinin.
Source Title: Cardiovascular Drugs and Therapy
URI: http://scholarbank.nus.edu.sg/handle/10635/112788
ISSN: 09203206
DOI: 10.1023/A:1027399707418
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