Please use this identifier to cite or link to this item:
|Title:||Dose-Dependent Effect of Aprotinin on Aggravated Pro-Inflammatory Cytokines in Patients with Pulmonary Hypertension Following Cardiopulmonary Bypass||Authors:||Lei, Y.
|Issue Date:||2003||Citation:||Lei, Y., Haider, H.Kh., Chusnsheng, W., Zhiqiang, C., Hao, C., Kejian, H., Qiang, Z. (2003). Dose-Dependent Effect of Aprotinin on Aggravated Pro-Inflammatory Cytokines in Patients with Pulmonary Hypertension Following Cardiopulmonary Bypass. Cardiovascular Drugs and Therapy 17 (4) : 343-348. ScholarBank@NUS Repository. https://doi.org/10.1023/A:1027399707418||Abstract:||Background: To investigate the dose dependent effect of aprotinin on aggravated pro-inflammatory cytokines in patients with pulmonary hypertension (PH) after cardiopulmonary bypass (CPB). Methods: Thirty-two patients with pulmonary arterial pressure (PAP) above 60 mmHg were recruited. They were assigned randomly to control (Group A, n = 8), and treated groups (Group B with aprotinin = 0.5 × 105 KIU/Kg, and Group C with aprotinin = 1.0 × 105 KIU/Kg, n = 12 each group). Blood samples were collected at various intervals of time and analyzed, from "0" hour (before CPB as baseline), at the completion of CPB, 4 hours and 24 hours after CPB, to measure the concentrations of interleukin 1β (IL-1β), interleukin-8 (IL-8), interleukin-10 (IL-10) and tumor necrosis factor-α (TNF-α). Results: All the biomarkers significantly increased after CPB. There was no significant difference in cytokine levels between Group A and group B after CPB. But IL-1β, IL-8 and TNF-α of Group C were not only significantly lower than Group A (p < 0.05), but also lower than Group B at various time points after CPB (p < 0.05). IL-10 of group C was significantly higher than Group A and Group B after CPB (p < 0.05). Conclusions: High dose aprotinin can suppress the release of pro-inflammatory cytokines IL-1β, IL-8 and TNF-α, and enhance the release of IL-10 in patients with PH after CPB. For patients having PH, there exists a simple and potential way to reduce the inflammatory response by applying high dose aprotinin.||Source Title:||Cardiovascular Drugs and Therapy||URI:||http://scholarbank.nus.edu.sg/handle/10635/112788||ISSN:||09203206||DOI:||10.1023/A:1027399707418|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Jun 17, 2019
WEB OF SCIENCETM
checked on Jun 17, 2019
checked on May 25, 2019
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.