Please use this identifier to cite or link to this item: https://doi.org/10.1021/nn102738c
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dc.titleThin films of functionalized multiwalled carbon nanotubes as suitable scaffold materials for stem cells proliferation and bone formation
dc.contributor.authorNayak, T.R.
dc.contributor.authorJian, L.
dc.contributor.authorPhua, L.C.
dc.contributor.authorHo, H.K.
dc.contributor.authorRen, Y.
dc.contributor.authorPastorin, G.
dc.date.accessioned2014-11-28T06:34:00Z
dc.date.available2014-11-28T06:34:00Z
dc.date.issued2010-12-28
dc.identifier.citationNayak, T.R., Jian, L., Phua, L.C., Ho, H.K., Ren, Y., Pastorin, G. (2010-12-28). Thin films of functionalized multiwalled carbon nanotubes as suitable scaffold materials for stem cells proliferation and bone formation. ACS Nano 4 (12) : 7717-7725. ScholarBank@NUS Repository. https://doi.org/10.1021/nn102738c
dc.identifier.issn19360851
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/112657
dc.description.abstractIn the field of regenerative medicine, human mesenchymal stem cells envisage extremely promising applications, due to their ability to differentiate into a wide range of connective tissue species on the basis of the substrate on which they grow. For the first time ever reported, we investigated the effects of a thin film of pegylated multiwalled carbon nanotubes spray dried onto preheated coverslips in terms of their ability to influence human mesenchymal stem cells' proliferation, morphology, and final differentiation into osteoblasts. Results clearly indicated that the homogeneous layer of functionalized nanotubes did not show any cytotoxicity and accelerated cell differentiation to a higher extent than carboxylated nanotubes or uncoated coverslips, by creating a more viable microenvironment for stem cells. Interestingly, cell differentiation occurred even in the absence of additional biochemical inducing agents, as evidenced by multiple independent criteria at the transcriptional, protein expression, and functional levels. Taken together, these findings suggest that functionalized carbon nanotubes represent a suitable scaffold toward a very selective differentiation into bone. © 2010 American Chemical Society.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1021/nn102738c
dc.sourceScopus
dc.subjectbone
dc.subjectcarbon nanotubes
dc.subjectcell differentiation
dc.subjectfunctionalization
dc.subjectmesenchymal stem cells
dc.subjectosteogenesis
dc.typeArticle
dc.contributor.departmentPHARMACY
dc.contributor.departmentNUS NANOSCIENCE & NANOTECH INITIATIVE
dc.description.doi10.1021/nn102738c
dc.description.sourcetitleACS Nano
dc.description.volume4
dc.description.issue12
dc.description.page7717-7725
dc.identifier.isiut000285449100085
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