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|Title:||A novel drug-eluting stent using bioabsorbable polymer technology: Two-year follow-up of the CURAMI registry||Authors:||Tin Hay, E.
|Issue Date:||9-Jan-2009||Citation:||Tin Hay, E., Hou, X.-M., Lim, J., Low, A., Teo, S.-G., Tan, H.-C., Lee, C.-H. (2009-01-09). A novel drug-eluting stent using bioabsorbable polymer technology: Two-year follow-up of the CURAMI registry. International Journal of Cardiology 131 (2) : 272-274. ScholarBank@NUS Repository. https://doi.org/10.1016/j.ijcard.2007.07.074||Abstract:||Background: There are safety concerns on drug-eluting stents (DESs) using durable polymer. The long-term outcome of next generation DESs using bioabsorbable polymer technology remains unknown. Methods: From March to June, 2005, a novel sirolimus-eluting (170 μg/cm2), bioabsorbable polymer (PLA and PLGA, eroded over 45 days) coated stent was implanted for treatment of acute myocardial infarction (AMI) in 49 patients (male 86%, age 55 + 10 years, diabetes 31%). All culprits were de novo lesions in the native coronary artery. On discharge, aspirin and clopidogrel for 3 months followed by life-long aspirin were prescribed. Angiographic follow-up was performed at 8 months. Clinical follow-up was performed at 4, 9 and 24 months. Results: Angiographic success rate was 100%. In-hospital adverse events consisted of 1 death (2%). All except one patient (due to aspirin allergy) were compliant to the 3 months dual antiplatelet therapy, and there was no adverse event during this period. One patient developed re-infarction in another coronary territory at 6 months. Twenty-seven patients (56%) underwent 8-month angiographic follow-up (Table 3). At 24 months, 6 patients had 7 major adverse cardiac events (12.2%, 1 death, 2 re-infarctions and 4 target lesion revascularizations). There were no incidences of subacute or late stent thrombosis. Conclusions: The Cura stent, using bioabsorbable polymer technology, appears to be safe at 2 years follow-up. Although the angiographic follow-up parameters were unfavorable, this report paves the way for further studies on DES using bioabsorbable polymer technology. © 2007 Elsevier Ireland Ltd. All rights reserved.||Source Title:||International Journal of Cardiology||URI:||http://scholarbank.nus.edu.sg/handle/10635/112211||ISSN:||01675273||DOI:||10.1016/j.ijcard.2007.07.074|
|Appears in Collections:||Staff Publications|
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