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Title: A novel drug-eluting stent using bioabsorbable polymer technology: Two-year follow-up of the CURAMI registry
Authors: Tin Hay, E.
Hou, X.-M.
Lim, J.
Low, A.
Teo, S.-G. 
Tan, H.-C.
Lee, C.-H.
Keywords: Bioabsorbable
Drug-eluting stent
Stent thrombosis
Issue Date: 9-Jan-2009
Citation: Tin Hay, E., Hou, X.-M., Lim, J., Low, A., Teo, S.-G., Tan, H.-C., Lee, C.-H. (2009-01-09). A novel drug-eluting stent using bioabsorbable polymer technology: Two-year follow-up of the CURAMI registry. International Journal of Cardiology 131 (2) : 272-274. ScholarBank@NUS Repository.
Abstract: Background: There are safety concerns on drug-eluting stents (DESs) using durable polymer. The long-term outcome of next generation DESs using bioabsorbable polymer technology remains unknown. Methods: From March to June, 2005, a novel sirolimus-eluting (170 μg/cm2), bioabsorbable polymer (PLA and PLGA, eroded over 45 days) coated stent was implanted for treatment of acute myocardial infarction (AMI) in 49 patients (male 86%, age 55 + 10 years, diabetes 31%). All culprits were de novo lesions in the native coronary artery. On discharge, aspirin and clopidogrel for 3 months followed by life-long aspirin were prescribed. Angiographic follow-up was performed at 8 months. Clinical follow-up was performed at 4, 9 and 24 months. Results: Angiographic success rate was 100%. In-hospital adverse events consisted of 1 death (2%). All except one patient (due to aspirin allergy) were compliant to the 3 months dual antiplatelet therapy, and there was no adverse event during this period. One patient developed re-infarction in another coronary territory at 6 months. Twenty-seven patients (56%) underwent 8-month angiographic follow-up (Table 3). At 24 months, 6 patients had 7 major adverse cardiac events (12.2%, 1 death, 2 re-infarctions and 4 target lesion revascularizations). There were no incidences of subacute or late stent thrombosis. Conclusions: The Cura stent, using bioabsorbable polymer technology, appears to be safe at 2 years follow-up. Although the angiographic follow-up parameters were unfavorable, this report paves the way for further studies on DES using bioabsorbable polymer technology. © 2007 Elsevier Ireland Ltd. All rights reserved.
Source Title: International Journal of Cardiology
ISSN: 01675273
DOI: 10.1016/j.ijcard.2007.07.074
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