Please use this identifier to cite or link to this item: https://doi.org/10.1001/archderm.130.2.210
DC FieldValue
dc.titleTranscriptional control and cell type specificity of HPV gene expression
dc.contributor.authorBernard, H.-U.
dc.contributor.authorApt, D.
dc.date.accessioned2014-11-28T02:54:20Z
dc.date.available2014-11-28T02:54:20Z
dc.date.issued1994
dc.identifier.citationBernard, H.-U., Apt, D. (1994). Transcriptional control and cell type specificity of HPV gene expression. Archives of Dermatology 130 (2) : 210-215. ScholarBank@NUS Repository. https://doi.org/10.1001/archderm.130.2.210
dc.identifier.issn0003987X
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/112199
dc.description.abstractBackground: Papillomaviruses are of great medical interest as they are causally associated with benign and malignant neoplasia of mucosal and cutaneous epithelia. The viral genome can be viewed as a control unit that releases signals in form of transforming proteins in infected epithelial cells. These proteins create a molecular environment favorable for papillomavirus biology and an expanded cell population for multiplication of the virus. On the other side, the genome receives signals through cellular transcription factors. Observations: Cellular transcription factors help the virus to identify the epithelial target cell, and they provide information about mitotic and physiologic signals to the epithelium and its differentiation state. Present research concentrates on the question how these distinct functions are brought about by factors that are ubiquitous rather than cell-type specific, such as NFI/CTF, TEF-1, AP-1, oct-1, and the progesterone receptor. Papillomaviruses have the additional capability to generate positive and negative feedback loops of gene expression through the virally encoded E2 proteins, a necessary tool to achieve long-term persistence. Conclusions: An intricate interplay between cellular and viral transcription factors is a prerequisite for epithelial specificity, physiologic responses, and persistence of papillomavirus infections.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1001/archderm.130.2.210
dc.sourceScopus
dc.typeReview
dc.contributor.departmentINSTITUTE OF MOLECULAR & CELL BIOLOGY
dc.description.doi10.1001/archderm.130.2.210
dc.description.sourcetitleArchives of Dermatology
dc.description.volume130
dc.description.issue2
dc.description.page210-215
dc.description.codenARDEA
dc.identifier.isiutA1994MV88100010
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