Please use this identifier to cite or link to this item: https://doi.org/10.1038/383050a0
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dc.titleRole of inscuteable in orienting asymmetric cell divisions in Drosophila
dc.contributor.authorKraut, R.
dc.contributor.authorChia, W.
dc.contributor.authorJan, L.Y.
dc.contributor.authorJan, Y.N.
dc.contributor.authorKnoblich, J.A.
dc.date.accessioned2014-11-28T02:54:17Z
dc.date.available2014-11-28T02:54:17Z
dc.date.issued1996-09-05
dc.identifier.citationKraut, R., Chia, W., Jan, L.Y., Jan, Y.N., Knoblich, J.A. (1996-09-05). Role of inscuteable in orienting asymmetric cell divisions in Drosophila. Nature 383 (6595) : 50-55. ScholarBank@NUS Repository. https://doi.org/10.1038/383050a0
dc.identifier.issn00280836
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/112195
dc.description.abstractDrosophila neuroblasts and epithelial cells in the procephalic neurogenic region divide perpendicular to the surface, and segregate the proteins Numb and Prospero into the basal daughter cell. We demonstrate here that orientation of the mitotic spindle and correct localization of Numb and Prospero in these cells require the inscuteable gene. Moreover, ectopic expression of inscuteable in other epithelial cells leads to spindle reorientation. The Inscuteable protein localizes to the apical cell cortex before mitosis, suggesting that Inscuteable functions in establishing polarity for asymmetric cell division.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1038/383050a0
dc.sourceScopus
dc.typeReview
dc.contributor.departmentINSTITUTE OF MOLECULAR & CELL BIOLOGY
dc.description.doi10.1038/383050a0
dc.description.sourcetitleNature
dc.description.volume383
dc.description.issue6595
dc.description.page50-55
dc.description.codenNATUA
dc.identifier.isiutA1996VF29500041
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