Please use this identifier to cite or link to this item: https://doi.org/10.1038/383050a0
Title: Role of inscuteable in orienting asymmetric cell divisions in Drosophila
Authors: Kraut, R. 
Chia, W. 
Jan, L.Y.
Jan, Y.N.
Knoblich, J.A.
Issue Date: 5-Sep-1996
Citation: Kraut, R., Chia, W., Jan, L.Y., Jan, Y.N., Knoblich, J.A. (1996-09-05). Role of inscuteable in orienting asymmetric cell divisions in Drosophila. Nature 383 (6595) : 50-55. ScholarBank@NUS Repository. https://doi.org/10.1038/383050a0
Abstract: Drosophila neuroblasts and epithelial cells in the procephalic neurogenic region divide perpendicular to the surface, and segregate the proteins Numb and Prospero into the basal daughter cell. We demonstrate here that orientation of the mitotic spindle and correct localization of Numb and Prospero in these cells require the inscuteable gene. Moreover, ectopic expression of inscuteable in other epithelial cells leads to spindle reorientation. The Inscuteable protein localizes to the apical cell cortex before mitosis, suggesting that Inscuteable functions in establishing polarity for asymmetric cell division.
Source Title: Nature
URI: http://scholarbank.nus.edu.sg/handle/10635/112195
ISSN: 00280836
DOI: 10.1038/383050a0
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

313
checked on Oct 22, 2021

WEB OF SCIENCETM
Citations

321
checked on Oct 13, 2021

Page view(s)

88
checked on Oct 14, 2021

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.