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|Title:||Viral nucleotide changes in asymptomatic hepatitis B carriers undergoing interferon treatment||Authors:||How, W.
|Issue Date:||1996||Citation:||How, W.,Ng, W.C.,Tan, M.F.,Seet, B.L.,Guan, R. (1996). Viral nucleotide changes in asymptomatic hepatitis B carriers undergoing interferon treatment. Alimentary Pharmacology and Therapeutics 10 (2) : 199-202. ScholarBank@NUS Repository.||Abstract:||Background: Interferon might induce mutation in regions of hepatitis B virus DNA that encode for immunologic target of cytotoxic T lymphocytes. Aim: To investigate the short-term effect of steroid priming and interferon therapy on hepatitis B virus, we followed the nucleotide changes in the precore and core region of hepatitis B virus DNA in seven healthy asymptomatic carriers who underwent steroid priming followed by recombinant alpha interferon for months. Methods: Hepatitis B virus DNA from serial sera of the patients were polymerase chain reaction-amplified, and the precore and core region directly sequenced and analysed. Results: Analysis revealed no serial changes in the hepatitis B virus nucleotide sequence in any of the patients. Conclusions: Steroid priming and short-term treatment with interferon in healthy asymptomatic patients does not select for hepatitis B virus with mutations in the precore and core region.||Source Title:||Alimentary Pharmacology and Therapeutics||URI:||http://scholarbank.nus.edu.sg/handle/10635/112160||ISSN:||02692813|
|Appears in Collections:||Staff Publications|
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