Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/112160
Title: Viral nucleotide changes in asymptomatic hepatitis B carriers undergoing interferon treatment
Authors: How, W.
Ng, W.C.
Tan, M.F. 
Seet, B.L.
Guan, R.
Issue Date: 1996
Citation: How, W.,Ng, W.C.,Tan, M.F.,Seet, B.L.,Guan, R. (1996). Viral nucleotide changes in asymptomatic hepatitis B carriers undergoing interferon treatment. Alimentary Pharmacology and Therapeutics 10 (2) : 199-202. ScholarBank@NUS Repository.
Abstract: Background: Interferon might induce mutation in regions of hepatitis B virus DNA that encode for immunologic target of cytotoxic T lymphocytes. Aim: To investigate the short-term effect of steroid priming and interferon therapy on hepatitis B virus, we followed the nucleotide changes in the precore and core region of hepatitis B virus DNA in seven healthy asymptomatic carriers who underwent steroid priming followed by recombinant alpha interferon for months. Methods: Hepatitis B virus DNA from serial sera of the patients were polymerase chain reaction-amplified, and the precore and core region directly sequenced and analysed. Results: Analysis revealed no serial changes in the hepatitis B virus nucleotide sequence in any of the patients. Conclusions: Steroid priming and short-term treatment with interferon in healthy asymptomatic patients does not select for hepatitis B virus with mutations in the precore and core region.
Source Title: Alimentary Pharmacology and Therapeutics
URI: http://scholarbank.nus.edu.sg/handle/10635/112160
ISSN: 02692813
Appears in Collections:Staff Publications

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