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|Title:||The role of a Drosophila POU homeo domain gene in the specification of neural precursor cell identity in the developing embryonic central nervous system||Authors:||Yang, X.
Neural precursor cells
POU homeo domain gene
|Issue Date:||1993||Citation:||Yang, X.,Yeo, S.,Dick, T.,Chia, W. (1993). The role of a Drosophila POU homeo domain gene in the specification of neural precursor cell identity in the developing embryonic central nervous system. Genes and Development 7 (3) : 504-516. ScholarBank@NUS Repository.||Abstract:||The Drosophila embryonic central nervous system (CNS) is derived from a Stereotypic array of progenitor stem cells called neuroblasts (NBs). Each of the ∼25 NBs per hemisegment undergoes repeated asymmetric divisions to produce, on average, 5-10 smaller ganglion mother cells (GMCs); each GMC, in turn, divides to produce two neurons. We demonstrate that the protein product encoded by a POU homeo domain gene (dPOU28/pdm-2) is expressed in the cell nuclei of a subset of NBs and GMCs. In the wild-type animal, GMC-1 is the only identified cell in the NB4-2 lineage that expresses dPOU28 protein to a high level, and it divides to produce the RF2 neuron and a second cell of unknown fate. Our results suggest that the presence of ectopically induced dPOU28/pdm-2 protein in the progeny of GMC-1 is sufficient to cause both of these cells to adopt their parental GMC-1 cell fate, leading to duplication of the RP2 neuron (and its sister cell) on the basis of both immunological and morphological criteria. These observations clearly implicate a role for dPOU28/pdm-2 in the specification of GMC-1 cell identity in the NB4-2 lineage and possibly in the specification of cell fate in other NB lineages in the developing embryonic CNS.||Source Title:||Genes and Development||URI:||http://scholarbank.nus.edu.sg/handle/10635/112133||ISSN:||08909369|
|Appears in Collections:||Staff Publications|
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