Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/112131
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dc.titleThe receptor-like protein tyrosine phosphatase α: A role in cell proliferation and oncogenesis
dc.contributor.authorPallen, C.J.
dc.date.accessioned2014-11-28T02:53:33Z
dc.date.available2014-11-28T02:53:33Z
dc.date.issued1993
dc.identifier.citationPallen, C.J. (1993). The receptor-like protein tyrosine phosphatase α: A role in cell proliferation and oncogenesis. Seminars in Cell and Developmental Biology 4 (6) : 403-408. ScholarBank@NUS Repository.
dc.identifier.issn10849521
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/112131
dc.description.abstractThe transmembrane nature of the receptor-like protein tyrosine phosphatases (PTPases) suggests that they transduce as yet unidentified extracellular signals to intracellular events via a phosphotyrosyl-protein dephosphorylation step, although little is known of their regulation and cellular activities. Structure/function studies of PTPα demonstrate that both catalytic domains are required for full enzymatic efficiency and that interdomain interactions may modulate PTPα activity and specificity. Overexpression of PTPα results in cell transformation and tumorigenesis, likely as a consequence of the ability of PTPα. to dephosphorylate and activate the c-src tyrosine kinase. This suggests a role for PTPα in normal cell proliferation. PTPα is so far unique among the PTPases in terms of its oncogenic potential, and overexpression or deregulation of PTPα may be involved in the genesis, progression or maintenance of certain tumor states.
dc.sourceScopus
dc.subjectCatalytic domains
dc.subjectOncogene
dc.subjectProtein tyrosine phosphatase
dc.subjectPTPα
dc.subjectReceptor-like
dc.typeArticle
dc.contributor.departmentINSTITUTE OF MOLECULAR & CELL BIOLOGY
dc.description.sourcetitleSeminars in Cell and Developmental Biology
dc.description.volume4
dc.description.issue6
dc.description.page403-408
dc.description.codenSCDBF
dc.identifier.isiutNOT_IN_WOS
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