Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/112090
Title: Structural and functional analysis of a promoter of the human granulin/epithelin gene
Authors: Bhandari, V.
Daniel, R.
Lim, P.S. 
Bateman, A.
Issue Date: 15-Oct-1996
Citation: Bhandari, V.,Daniel, R.,Lim, P.S.,Bateman, A. (1996-10-15). Structural and functional analysis of a promoter of the human granulin/epithelin gene. Biochemical Journal 319 (2) : 441-447. ScholarBank@NUS Repository.
Abstract: Granulins (grns) or epithelins (epis) are peptides with molecular masses of approx. 6 kDa that modulate the growth of cells. The precursor for the grns/epis, which might itself be biologically active, is a secreted glycoprotein containing multiple repeats of the grn/epi motif. Grn/epi mRNA occurs widely in vivo, particularly in tissues rich in epithelial and haematopoietic cells. To understand better the role of the gene products for grn/epi it is important to determine the patterns of grn/epi gene expression and how this is regulated. To assist in this we have obtained the 5' sequence of the human grn/epi gene, and using chimaeras of the grn/epi -5' sequence and the chloramphenicol acetyltransferase gene we have shown a strong promoter activity associated with the 5' sequence of the human grn/epi gene, We have further delineated regions of the 5' sequence that confer high-level expression on the chimaeric gene.
Source Title: Biochemical Journal
URI: http://scholarbank.nus.edu.sg/handle/10635/112090
ISSN: 02646021
Appears in Collections:Staff Publications

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