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|Title:||Solid-phase synthesis of tetramic acids||Authors:||Kulkarni, B.A.
|Issue Date:||11-Jun-1998||Citation:||Kulkarni, B.A., Ganesan, A. (1998-06-11). Solid-phase synthesis of tetramic acids. Tetrahedron Letters 39 (24) : 4369-4372. ScholarBank@NUS Repository. https://doi.org/10.1016/S0040-4039(98)00703-5||Abstract:||Upon treatment with base, N-acylated α-amino acids loaded on Wang resin undergo cyclative Claisen-type condensation to release the tetrarnic acid in high yield and purity. The use of tetrabutylammonium hydroxide as base simplifies product purification, as it can be scavenged by acidic Amberlyst A-15 ion exchange resin. The diversity of the tetramic acids can be further increased by reductive alkylation of the starting amino acid.||Source Title:||Tetrahedron Letters||URI:||http://scholarbank.nus.edu.sg/handle/10635/112078||ISSN:||00404039||DOI:||10.1016/S0040-4039(98)00703-5|
|Appears in Collections:||Staff Publications|
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