Solid-phase synthesis of tetramic acids

Please use this identifier to cite or link to this item: https://doi.org/10.1016/S0040-4039(98)00703-5

Title:	Solid-phase synthesis of tetramic acids
Authors:	Kulkarni, B.A. Ganesan, A.
Keywords:	Combinatorial chemistry Condensations Pyrrolidinones Solid-phase synthesis
Issue Date:	11-Jun-1998
Citation:	Kulkarni, B.A., Ganesan, A. (1998-06-11). Solid-phase synthesis of tetramic acids. Tetrahedron Letters 39 (24) : 4369-4372. ScholarBank@NUS Repository. https://doi.org/10.1016/S0040-4039(98)00703-5
Abstract:	Upon treatment with base, N-acylated α-amino acids loaded on Wang resin undergo cyclative Claisen-type condensation to release the tetrarnic acid in high yield and purity. The use of tetrabutylammonium hydroxide as base simplifies product purification, as it can be scavenged by acidic Amberlyst A-15 ion exchange resin. The diversity of the tetramic acids can be further increased by reductive alkylation of the starting amino acid.
Source Title:	Tetrahedron Letters
URI:	http://scholarbank.nus.edu.sg/handle/10635/112078
ISSN:	00404039
DOI:	10.1016/S0040-4039(98)00703-5
Appears in Collections:	Staff Publications

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