Please use this identifier to cite or link to this item: https://doi.org/10.1016/S0040-4039(98)00703-5
Title: Solid-phase synthesis of tetramic acids
Authors: Kulkarni, B.A. 
Ganesan, A. 
Keywords: Combinatorial chemistry
Condensations
Pyrrolidinones
Solid-phase synthesis
Issue Date: 11-Jun-1998
Citation: Kulkarni, B.A., Ganesan, A. (1998-06-11). Solid-phase synthesis of tetramic acids. Tetrahedron Letters 39 (24) : 4369-4372. ScholarBank@NUS Repository. https://doi.org/10.1016/S0040-4039(98)00703-5
Abstract: Upon treatment with base, N-acylated α-amino acids loaded on Wang resin undergo cyclative Claisen-type condensation to release the tetrarnic acid in high yield and purity. The use of tetrabutylammonium hydroxide as base simplifies product purification, as it can be scavenged by acidic Amberlyst A-15 ion exchange resin. The diversity of the tetramic acids can be further increased by reductive alkylation of the starting amino acid.
Source Title: Tetrahedron Letters
URI: http://scholarbank.nus.edu.sg/handle/10635/112078
ISSN: 00404039
DOI: 10.1016/S0040-4039(98)00703-5
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