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https://doi.org/10.1016/S0960-894X(98)00408-9
Title: | Solid-phase synthesis of potential protein tyrosine phosphatase inhibitors via the Ugi four-component condensation | Authors: | Li, Z. Yeo, S.L. Pallen, C.J. Ganesan, A. |
Keywords: | Enzyme inhibitors Phosphonic acids and derivs Solid phase synthesis |
Issue Date: | 22-Sep-1998 | Citation: | Li, Z., Yeo, S.L., Pallen, C.J., Ganesan, A. (1998-09-22). Solid-phase synthesis of potential protein tyrosine phosphatase inhibitors via the Ugi four-component condensation. Bioorganic and Medicinal Chemistry Letters 8 (18) : 2443-2446. ScholarBank@NUS Repository. https://doi.org/10.1016/S0960-894X(98)00408-9 | Abstract: | A library of 108 α,α-difluoromethylenephosphonic acids was prepared by Ugi four-component condensation using Rink-NH2 resin, 4- [(diethoxyphosphinyl)difluoromethyl]benzoic acid, and a set of 18 aldehydes and 6 isonitriles. Following resin cleavage, the diethylphosphonate esters were hydrolyzed with trimethylsilyl bromide to yield the free acids which were assayed for inhibition of PTPα, PTPβ and PTPε. | Source Title: | Bioorganic and Medicinal Chemistry Letters | URI: | http://scholarbank.nus.edu.sg/handle/10635/112077 | ISSN: | 0960894X | DOI: | 10.1016/S0960-894X(98)00408-9 |
Appears in Collections: | Staff Publications |
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