Please use this identifier to cite or link to this item: https://doi.org/10.1016/S0960-894X(98)00408-9
Title: Solid-phase synthesis of potential protein tyrosine phosphatase inhibitors via the Ugi four-component condensation
Authors: Li, Z.
Yeo, S.L.
Pallen, C.J. 
Ganesan, A. 
Keywords: Enzyme inhibitors
Phosphonic acids and derivs
Solid phase synthesis
Issue Date: 22-Sep-1998
Citation: Li, Z., Yeo, S.L., Pallen, C.J., Ganesan, A. (1998-09-22). Solid-phase synthesis of potential protein tyrosine phosphatase inhibitors via the Ugi four-component condensation. Bioorganic and Medicinal Chemistry Letters 8 (18) : 2443-2446. ScholarBank@NUS Repository. https://doi.org/10.1016/S0960-894X(98)00408-9
Abstract: A library of 108 α,α-difluoromethylenephosphonic acids was prepared by Ugi four-component condensation using Rink-NH2 resin, 4- [(diethoxyphosphinyl)difluoromethyl]benzoic acid, and a set of 18 aldehydes and 6 isonitriles. Following resin cleavage, the diethylphosphonate esters were hydrolyzed with trimethylsilyl bromide to yield the free acids which were assayed for inhibition of PTPα, PTPβ and PTPε.
Source Title: Bioorganic and Medicinal Chemistry Letters
URI: http://scholarbank.nus.edu.sg/handle/10635/112077
ISSN: 0960894X
DOI: 10.1016/S0960-894X(98)00408-9
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