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https://doi.org/10.1016/S0040-4039(98)01320-3
Title: | Solid-phase combinatorial synthesis of 4-hydroxyquinolin-2(1H)-ones | Authors: | Sim, M.M. Lee, C.L. Ganesan, A. |
Keywords: | Acylation Combinatorial chemistry Quinolinones Solid-phase synthesis |
Issue Date: | 27-Aug-1998 | Citation: | Sim, M.M., Lee, C.L., Ganesan, A. (1998-08-27). Solid-phase combinatorial synthesis of 4-hydroxyquinolin-2(1H)-ones. Tetrahedron Letters 39 (35) : 6399-6402. ScholarBank@NUS Repository. https://doi.org/10.1016/S0040-4039(98)01320-3 | Abstract: | Cyanoacetic acid was loaded on Wang resin and C-acylated using acid anhydrides and triethylamine as base. Resin cleavage with concomitant decarboxylation produces β-keto nitriles. In the case of isatoic anhydrides, the resin-bound acylated intermediates undergo cyclative cleavage upon heating, leading to 4hydroxyquinolin-2(1H)-ones. | Source Title: | Tetrahedron Letters | URI: | http://scholarbank.nus.edu.sg/handle/10635/112075 | ISSN: | 00404039 | DOI: | 10.1016/S0040-4039(98)01320-3 |
Appears in Collections: | Staff Publications |
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