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|Title:||Solid-phase combinatorial synthesis of 4-hydroxyquinolin-2(1H)-ones||Authors:||Sim, M.M.
|Issue Date:||27-Aug-1998||Citation:||Sim, M.M., Lee, C.L., Ganesan, A. (1998-08-27). Solid-phase combinatorial synthesis of 4-hydroxyquinolin-2(1H)-ones. Tetrahedron Letters 39 (35) : 6399-6402. ScholarBank@NUS Repository. https://doi.org/10.1016/S0040-4039(98)01320-3||Abstract:||Cyanoacetic acid was loaded on Wang resin and C-acylated using acid anhydrides and triethylamine as base. Resin cleavage with concomitant decarboxylation produces β-keto nitriles. In the case of isatoic anhydrides, the resin-bound acylated intermediates undergo cyclative cleavage upon heating, leading to 4hydroxyquinolin-2(1H)-ones.||Source Title:||Tetrahedron Letters||URI:||http://scholarbank.nus.edu.sg/handle/10635/112075||ISSN:||00404039||DOI:||10.1016/S0040-4039(98)01320-3|
|Appears in Collections:||Staff Publications|
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