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Title: Solid-phase combinatorial synthesis of 4-hydroxyquinolin-2(1H)-ones
Authors: Sim, M.M. 
Lee, C.L.
Ganesan, A. 
Keywords: Acylation
Combinatorial chemistry
Solid-phase synthesis
Issue Date: 27-Aug-1998
Citation: Sim, M.M., Lee, C.L., Ganesan, A. (1998-08-27). Solid-phase combinatorial synthesis of 4-hydroxyquinolin-2(1H)-ones. Tetrahedron Letters 39 (35) : 6399-6402. ScholarBank@NUS Repository.
Abstract: Cyanoacetic acid was loaded on Wang resin and C-acylated using acid anhydrides and triethylamine as base. Resin cleavage with concomitant decarboxylation produces β-keto nitriles. In the case of isatoic anhydrides, the resin-bound acylated intermediates undergo cyclative cleavage upon heating, leading to 4hydroxyquinolin-2(1H)-ones.
Source Title: Tetrahedron Letters
ISSN: 00404039
DOI: 10.1016/S0040-4039(98)01320-3
Appears in Collections:Staff Publications

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