Please use this identifier to cite or link to this item:
https://doi.org/10.1016/S0040-4039(98)01320-3
| Title: | Solid-phase combinatorial synthesis of 4-hydroxyquinolin-2(1H)-ones | Authors: | Sim, M.M. Lee, C.L. Ganesan, A. |
Keywords: | Acylation Combinatorial chemistry Quinolinones Solid-phase synthesis |
Issue Date: | 27-Aug-1998 | Citation: | Sim, M.M., Lee, C.L., Ganesan, A. (1998-08-27). Solid-phase combinatorial synthesis of 4-hydroxyquinolin-2(1H)-ones. Tetrahedron Letters 39 (35) : 6399-6402. ScholarBank@NUS Repository. https://doi.org/10.1016/S0040-4039(98)01320-3 | Abstract: | Cyanoacetic acid was loaded on Wang resin and C-acylated using acid anhydrides and triethylamine as base. Resin cleavage with concomitant decarboxylation produces β-keto nitriles. In the case of isatoic anhydrides, the resin-bound acylated intermediates undergo cyclative cleavage upon heating, leading to 4hydroxyquinolin-2(1H)-ones. | Source Title: | Tetrahedron Letters | URI: | http://scholarbank.nus.edu.sg/handle/10635/112075 | ISSN: | 00404039 | DOI: | 10.1016/S0040-4039(98)01320-3 |
| Appears in Collections: | Staff Publications |
Show full item record
Files in This Item:
There are no files associated with this item.
SCOPUSTM
Citations
39
checked on Jan 29, 2023
WEB OF SCIENCETM
Citations
32
checked on Jan 20, 2023
Page view(s)
122
checked on Jan 26, 2023
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.