Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/112070
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dc.titleSequence variants of human pappillomavirus virus type 16 from couples suggest sexual transmission with low infectivity and polyclonality in genital neoplasia
dc.contributor.authorHo, L.
dc.contributor.authorTay, S.-K.
dc.contributor.authorChan, S.-Y.
dc.contributor.authorBernard, H.-U.
dc.date.accessioned2014-11-28T02:52:51Z
dc.date.available2014-11-28T02:52:51Z
dc.date.issued1993-10
dc.identifier.citationHo, L.,Tay, S.-K.,Chan, S.-Y.,Bernard, H.-U. (1993-10). Sequence variants of human pappillomavirus virus type 16 from couples suggest sexual transmission with low infectivity and polyclonality in genital neoplasia. Journal of Infectious Diseases 168 (4) : 803-809. ScholarBank@NUS Repository.
dc.identifier.issn00221899
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/112070
dc.description.abstractHuman papillomavirus type 16 (HPV-16) is causally involved in the pathogenesis of genital neoplasia, but important details of the natural history of infection and disease are not yet understood. Many individual HPV-16 DNA isolates differ by characteristic point mutations. In a study of the HPV-16 variants from genital lesions of 32 married couples, HPV-16 was detected in both the husband and the wife in 8 couples. Of these, 4 demonstrated identical HPV-16 variants between husband and wife, and 4 had mismatching HPV-16 variants. Five of 31 biopsies showed simultaneous presence of two different HPV-16 variants. The data suggest that sexual transmission of HPV-16 does occur, but with low infectivity, and that HPV-16-related premalignant lesions are frequently polyclonal.
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentINSTITUTE OF MOLECULAR & CELL BIOLOGY
dc.description.sourcetitleJournal of Infectious Diseases
dc.description.volume168
dc.description.issue4
dc.description.page803-809
dc.description.codenJIDIA
dc.identifier.isiutNOT_IN_WOS
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