Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/112070
Title: Sequence variants of human pappillomavirus virus type 16 from couples suggest sexual transmission with low infectivity and polyclonality in genital neoplasia
Authors: Ho, L.
Tay, S.-K.
Chan, S.-Y.
Bernard, H.-U. 
Issue Date: Oct-1993
Citation: Ho, L.,Tay, S.-K.,Chan, S.-Y.,Bernard, H.-U. (1993-10). Sequence variants of human pappillomavirus virus type 16 from couples suggest sexual transmission with low infectivity and polyclonality in genital neoplasia. Journal of Infectious Diseases 168 (4) : 803-809. ScholarBank@NUS Repository.
Abstract: Human papillomavirus type 16 (HPV-16) is causally involved in the pathogenesis of genital neoplasia, but important details of the natural history of infection and disease are not yet understood. Many individual HPV-16 DNA isolates differ by characteristic point mutations. In a study of the HPV-16 variants from genital lesions of 32 married couples, HPV-16 was detected in both the husband and the wife in 8 couples. Of these, 4 demonstrated identical HPV-16 variants between husband and wife, and 4 had mismatching HPV-16 variants. Five of 31 biopsies showed simultaneous presence of two different HPV-16 variants. The data suggest that sexual transmission of HPV-16 does occur, but with low infectivity, and that HPV-16-related premalignant lesions are frequently polyclonal.
Source Title: Journal of Infectious Diseases
URI: http://scholarbank.nus.edu.sg/handle/10635/112070
ISSN: 00221899
Appears in Collections:Staff Publications

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