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|Title:||Sequence variants of human pappillomavirus virus type 16 from couples suggest sexual transmission with low infectivity and polyclonality in genital neoplasia||Authors:||Ho, L.
|Issue Date:||Oct-1993||Citation:||Ho, L.,Tay, S.-K.,Chan, S.-Y.,Bernard, H.-U. (1993-10). Sequence variants of human pappillomavirus virus type 16 from couples suggest sexual transmission with low infectivity and polyclonality in genital neoplasia. Journal of Infectious Diseases 168 (4) : 803-809. ScholarBank@NUS Repository.||Abstract:||Human papillomavirus type 16 (HPV-16) is causally involved in the pathogenesis of genital neoplasia, but important details of the natural history of infection and disease are not yet understood. Many individual HPV-16 DNA isolates differ by characteristic point mutations. In a study of the HPV-16 variants from genital lesions of 32 married couples, HPV-16 was detected in both the husband and the wife in 8 couples. Of these, 4 demonstrated identical HPV-16 variants between husband and wife, and 4 had mismatching HPV-16 variants. Five of 31 biopsies showed simultaneous presence of two different HPV-16 variants. The data suggest that sexual transmission of HPV-16 does occur, but with low infectivity, and that HPV-16-related premalignant lesions are frequently polyclonal.||Source Title:||Journal of Infectious Diseases||URI:||http://scholarbank.nus.edu.sg/handle/10635/112070||ISSN:||00221899|
|Appears in Collections:||Staff Publications|
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