Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/112045
Title: Regulation of HLA class I gene expression in human colorectal carcinoma
Authors: Soong, T.W. 
Oei, A.A. 
Hui, K.M. 
Keywords: Colorectal cancer
HLA class I
Locus-specific suppression
Non-coordinated
Trans-acting elements
Issue Date: Feb-1991
Citation: Soong, T.W., Oei, A.A., Hui, K.M. (1991-02). Regulation of HLA class I gene expression in human colorectal carcinoma. Seminars in Cancer Biology 2 (1) : 23-33. ScholarBank@NUS Repository.
Abstract: The under-representation of HLA antigens in human tumors is usually associated with a poor prognosis. In this report, the expression of HLA class I genes in human colorectal carcinomas was studied using HLA-A and HLA-B locus-specific probes. Over 50% of the colorectal carcinomas studied showed a reduction in the amount of steady state HLA class I mRNA. For some carcinomas, non-coordinated regulation of the HLA-A and HLA-B genes was observed. The mechanism of HLA suppression was investigated and is most likely due to the presence of transcriptional regulatory elements. © 1991 by W.B. Saunders Company.
Source Title: Seminars in Cancer Biology
URI: http://scholarbank.nus.edu.sg/handle/10635/112045
ISSN: 1044579X
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

Page view(s)

44
checked on Dec 2, 2021

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.