Please use this identifier to cite or link to this item:
|Title:||Regulation of HLA class I gene expression in human colorectal carcinoma||Authors:||Soong, T.W.
HLA class I
|Issue Date:||Feb-1991||Citation:||Soong, T.W., Oei, A.A., Hui, K.M. (1991-02). Regulation of HLA class I gene expression in human colorectal carcinoma. Seminars in Cancer Biology 2 (1) : 23-33. ScholarBank@NUS Repository.||Abstract:||The under-representation of HLA antigens in human tumors is usually associated with a poor prognosis. In this report, the expression of HLA class I genes in human colorectal carcinomas was studied using HLA-A and HLA-B locus-specific probes. Over 50% of the colorectal carcinomas studied showed a reduction in the amount of steady state HLA class I mRNA. For some carcinomas, non-coordinated regulation of the HLA-A and HLA-B genes was observed. The mechanism of HLA suppression was investigated and is most likely due to the presence of transcriptional regulatory elements. © 1991 by W.B. Saunders Company.||Source Title:||Seminars in Cancer Biology||URI:||http://scholarbank.nus.edu.sg/handle/10635/112045||ISSN:||1044579X|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Dec 2, 2021
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.