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Title: Regulation of HLA class I gene expression in human colorectal carcinoma
Authors: Soong, T.W. 
Oei, A.A. 
Hui, K.M. 
Keywords: Colorectal cancer
HLA class I
Locus-specific suppression
Trans-acting elements
Issue Date: Feb-1991
Citation: Soong, T.W., Oei, A.A., Hui, K.M. (1991-02). Regulation of HLA class I gene expression in human colorectal carcinoma. Seminars in Cancer Biology 2 (1) : 23-33. ScholarBank@NUS Repository.
Abstract: The under-representation of HLA antigens in human tumors is usually associated with a poor prognosis. In this report, the expression of HLA class I genes in human colorectal carcinomas was studied using HLA-A and HLA-B locus-specific probes. Over 50% of the colorectal carcinomas studied showed a reduction in the amount of steady state HLA class I mRNA. For some carcinomas, non-coordinated regulation of the HLA-A and HLA-B genes was observed. The mechanism of HLA suppression was investigated and is most likely due to the presence of transcriptional regulatory elements. © 1991 by W.B. Saunders Company.
Source Title: Seminars in Cancer Biology
ISSN: 1044579X
Appears in Collections:Staff Publications

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