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https://doi.org/10.1006/scdb.1996.0086
Title: | Regulation of actin cytoskeleton by Rho-family GTPases and their associated proteins | Authors: | Lim, L. Hall, C. Monfries, C. |
Keywords: | Actin morphology Chimaerin PAK Rho GTPases ROK |
Issue Date: | Oct-1996 | Citation: | Lim, L., Hall, C., Monfries, C. (1996-10). Regulation of actin cytoskeleton by Rho-family GTPases and their associated proteins. Seminars in Cell and Developmental Biology 7 (5) : 699-706. ScholarBank@NUS Repository. https://doi.org/10.1006/scdb.1996.0086 | Abstract: | Cdc42, Rac and Rho GTPase each regulates distinct morphological changes in response to specific growth factors. These changes which involve actin-containing cytoskeletal structures may underlie aspects of growth and development. Proteins binding to the active GTP-bound form of the GTPase including the Cdc42/ Rac activated PAK, and the Rho associated kinase ROK can act as morphological effectors as can the RacGAP chimaerin. In fibroblasts and neuronal-type cells, the growth factors evoke morphological changes by activating individual GTPase pathways or Rac-Rho and Cdc42-Rac hierarchical pathways. There is also evidence for Cdc42-Rho antagonism. The morphological outcome will depend on the level of activation of the different GT Pases by their stimulatory growth factor. | Source Title: | Seminars in Cell and Developmental Biology | URI: | http://scholarbank.nus.edu.sg/handle/10635/112043 | ISSN: | 10849521 | DOI: | 10.1006/scdb.1996.0086 |
Appears in Collections: | Staff Publications |
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