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https://scholarbank.nus.edu.sg/handle/10635/111993
Title: | Novel human brain cDNA encoding a 34,000 Mr protein n-chimaerin, related to both the regulatory domain of protein kinase C and BCR, the product of the breakpoint cluster region gene | Authors: | Hall, C. Monfries, C. Smith, P. Lim, H.H. Kozma, R. Ahmed, S. Vanniasingham, V. Leung, T. Lim, L. |
Issue Date: | 1990 | Citation: | Hall, C.,Monfries, C.,Smith, P.,Lim, H.H.,Kozma, R.,Ahmed, S.,Vanniasingham, V.,Leung, T.,Lim, L. (1990). Novel human brain cDNA encoding a 34,000 Mr protein n-chimaerin, related to both the regulatory domain of protein kinase C and BCR, the product of the breakpoint cluster region gene. Journal of Molecular Biology 211 (1) : 11-16. ScholarBank@NUS Repository. | Abstract: | A novel human brain complementary DNA sequence encodes n-chimaerin, a 34,000 Mr protein. A single cysteine-rich sequence CX2CX13CX2CX7CX7C in the N-terminal half of n-chimaerin shares almost 50% identity with corresponding sequences in the C1 regulatory domain of protein kinase C. The C-terminal half of n-chimaerin has 42% identity with the C-terminal region (amino acid residues 1050 to 1225) of BCR, the product of the breakpoint cluster region gene involved in Philadelphia (Ph′) chromosome translocation. n-Chimaerin mRNA (2.2 × 103 base-pairs) is specifically expressed in the brain, with the highest amounts being in the hippocampus and cerebral cortex. The mRNA has a neuronal distribution and is expressed in neuroblastoma cells, but not in C6 glioma or primary astrocyte cultures. The similarity of two separate regions of n-chimaerin to domains of protein kinase C and BCR has intriguing implications with respect to its evolutionary origins, its function in the brain and potential phorbol-ester-binding properties. | Source Title: | Journal of Molecular Biology | URI: | http://scholarbank.nus.edu.sg/handle/10635/111993 | ISSN: | 00222836 |
Appears in Collections: | Staff Publications |
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