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|Title:||Isolation, characterization and evolution of nine pufferfish (Fugu rubripes) actin genes||Authors:||Venkatesh, B.
Evolution of actins
|Issue Date:||21-Jun-1996||Citation:||Venkatesh, B., Tay, B.H., Elgar, G., Brenner, S. (1996-06-21). Isolation, characterization and evolution of nine pufferfish (Fugu rubripes) actin genes. Journal of Molecular Biology 259 (4) : 655-665. ScholarBank@NUS Repository. https://doi.org/10.1006/jmbi.1996.0347||Abstract:||The Japanese pufferfish Fugu rubripes (Fugu) has a small genome of about 400 Mb. Nine different actin genes have been isolated and sequenced from a genomic library constructed from this teleost. The six muscle-type actin genes include two α-skeletal actins, three cc-cardiac actins and an α-anomalous (testis type) actin, and the three cytoplasmic actins include two β-cytoplasmic actins and a β-cytoplasmic (vascular type) actin. The two skeletal muscle actin genes have identical genomic organization, but differ by five amino acid residues. The three cardiac actin genes code for the same protein but differ in their nucleotide sequences and genomic organization. β-Cytoplasmic actin1 differs by three amino acids from β-cytoplasmic actin2. The α-anomalous (testis type) and β-cytoplasmic (vascular type) actins are novel vertebrate actins. The amino acid sequence of α-anomalous (testis type) actin is the most divergent of all the known vertebrate actins and transcripts of this gene are abundant in the testis. The β-cytoplasmic (vascular type) actin gene has eight introns, similar to mammalian smooth muscle actins, and is expressed in vascular tissues such as the gills, kidney and skin. Several known regulatory elements are found in the 5' flanking sequences and the first intron of various Fugu actin genes. The intron patterns of the various Fugu actins seem to be the result of loss of certain introns from a common ancestral gene.||Source Title:||Journal of Molecular Biology||URI:||http://scholarbank.nus.edu.sg/handle/10635/111954||ISSN:||00222836||DOI:||10.1006/jmbi.1996.0347|
|Appears in Collections:||Staff Publications|
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