Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/111939
DC FieldValue
dc.titleIncreased mRNA expression of the receptor-like protein tyrosine phosphatase α in late stage colon carcinomas
dc.contributor.authorTabiti, K.
dc.contributor.authorSmith, D.R.
dc.contributor.authorGoh, H.-S.
dc.contributor.authorPallen, C.J.
dc.date.accessioned2014-11-28T02:51:22Z
dc.date.available2014-11-28T02:51:22Z
dc.date.issued1995-07-13
dc.identifier.citationTabiti, K.,Smith, D.R.,Goh, H.-S.,Pallen, C.J. (1995-07-13). Increased mRNA expression of the receptor-like protein tyrosine phosphatase α in late stage colon carcinomas. Cancer Letters 93 (2) : 239-248. ScholarBank@NUS Repository.
dc.identifier.issn03043835
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/111939
dc.description.abstractThe protein tyrosine phosphatase α (PTPα) mRNA level in paired samples of late stage (Dukes' D) colorectal tumors and adjacent normal colon mucosa was quantified by RNase protection assays. After normalization against 18S RNA or β-actin mRNA level, a 2-10-fold increase in PTPα mRNA was detected in 10 of 14 tumors (~ 70%) compared to mucosa. In situ hybridization of digoxigenin-labelled antisense PTPα RNA to tumor and mucosa sections produced a signal only in neoplastic cells of the tumor sample, consistent with the high increase in PTPα mRNA detected by RNase protection assays of some of the tumors. This is the first report suggesting an association of a protein tyrosine phosphatase with colorectal carcinoma. PTPα is a receptor-like PTP thought to be involved in regulating cell proliferation. Its oncogenic properties when overexpressed in cultured fibroblasts suggest that PTPα overexpression could contribute to the tumorigenic process in colon carcinoma. © 1995.
dc.sourceScopus
dc.subjectColon carcinoma
dc.subjectOncogene
dc.subjectProtein tyrosine phosphatase
dc.typeArticle
dc.contributor.departmentINSTITUTE OF MOLECULAR & CELL BIOLOGY
dc.description.sourcetitleCancer Letters
dc.description.volume93
dc.description.issue2
dc.description.page239-248
dc.description.codenCALED
dc.identifier.isiutNOT_IN_WOS
Appears in Collections:Staff Publications

Show simple item record
Files in This Item:
There are no files associated with this item.

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.