Please use this identifier to cite or link to this item: https://doi.org/10.1002/ijc.2910610403
DC FieldValue
dc.titleHuman papillomaviruses in 91 oral cancers from indican betel quid chewers - High prevalence and multiplicity of infections
dc.contributor.authorBalaram, P.
dc.contributor.authorNalinakumari, K.R.
dc.contributor.authorAbraham, E.
dc.contributor.authorBalan, A.
dc.contributor.authorHareendran, N.K.
dc.contributor.authorBernard, H.-U.
dc.contributor.authorChan, S.-Y.
dc.date.accessioned2014-11-28T02:51:11Z
dc.date.available2014-11-28T02:51:11Z
dc.date.issued1995
dc.identifier.citationBalaram, P., Nalinakumari, K.R., Abraham, E., Balan, A., Hareendran, N.K., Bernard, H.-U., Chan, S.-Y. (1995). Human papillomaviruses in 91 oral cancers from indican betel quid chewers - High prevalence and multiplicity of infections. International Journal of Cancer 61 (4) : 450-454. ScholarBank@NUS Repository. https://doi.org/10.1002/ijc.2910610403
dc.identifier.issn00207136
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/111922
dc.description.abstractIndia has one of the world's highest incidences of oral cancer. The habbit of chewing betel quid is widespread and is suspected to play a role in the etiology of this disease. Studies in many other countries have also pointed to a role for human papillomaviruses viruses (HPVs) in the etiology of some oral cancers. In this study we analyzed biopsies from 91 Indian oral cancer patients, most of whom were betel quid chewers, by PCR amplification and direct DNA sequencing. HPV DNA was detected in 74% of these lesions, of which 41% had multiple HPV infections. Among the lesions from different oral sites, lesions of the tongue had the highest rate (9 of 11) of HPV infection. These HPV prevalences are among the highest ever reported in oral cancers. As to individual HPV types, prevalences of HPV-6, HPV-11, HPV-16 and HPV-18 were 13%, 20%, 42% and 47%, respectively. No additional known or novel HPV types were detected. To understand the unexpectedly high prevalences of the 'low-risk' types HPV-6 and HPV-11, we compared the subtypes and variants that were found in oral cancers against those from benign genital warts from the same patient population but found no differences. The high prevalence of HPV in the oral cancers of these Indian patients suggests that viral infection is an important etiological component, with betel quid probably causing additional mutagenic steps in the carcinogenic process.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1002/ijc.2910610403
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentINSTITUTE OF MOLECULAR & CELL BIOLOGY
dc.description.doi10.1002/ijc.2910610403
dc.description.sourcetitleInternational Journal of Cancer
dc.description.volume61
dc.description.issue4
dc.description.page450-454
dc.description.codenIJCNA
dc.identifier.isiutA1995QZ92800002
Appears in Collections:Staff Publications

Show simple item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

167
checked on Oct 16, 2020

WEB OF SCIENCETM
Citations

144
checked on Oct 16, 2020

Page view(s)

72
checked on Oct 23, 2020

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.