Please use this identifier to cite or link to this item: https://doi.org/10.1074/jbc.M212050200
Title: Human growth hormone-regulated HOXA1 is a human mammary epithelial oncogene
Authors: Zhang, X.
Zhu, T. 
Chen, Y.
Mertani, H.C.
Lee, K.-O.
Lobie, P.E. 
Issue Date: 28-Feb-2003
Citation: Zhang, X., Zhu, T., Chen, Y., Mertani, H.C., Lee, K.-O., Lobie, P.E. (2003-02-28). Human growth hormone-regulated HOXA1 is a human mammary epithelial oncogene. Journal of Biological Chemistry 278 (9) : 7580-7590. ScholarBank@NUS Repository. https://doi.org/10.1074/jbc.M212050200
Abstract: Increased mammary epithelial expression of the human growth hormone (hGH) gene is associated with the acquisition of pathological proliferation. We report here that autocrine hGH production by human mammary carcinoma cells increased the expression and transcriptional activity of the homeobox domain containing protein HOXA1. Forced expression of HOXA1 in human mammary carcinoma cells resulted in increased total cell number primarily by the promotion of cell survival mediated by the transcriptional up-regulation of Bcl-2. HOXA1 also abrogated the apoptotic response of mammary carcinoma cells to doxorubicin. Forced expression of HOXA1 in mammary carcinoma cells, in a Bcl-2-dependent manner, resulted in dramatic enhancement of anchorage-independent proliferation and colony formation in soft agar. Finally, forced expression of HOXA1 was sufficient to result in the oncogenic transformation of immortalized human mammary epithelial cells with aggressive in vivo tumor formation. Herein, we have therefore provided a molecular mechanism by which autocrine hGH stimulation of human mammary epithelial cells may result in oncogenic transformation.
Source Title: Journal of Biological Chemistry
URI: http://scholarbank.nus.edu.sg/handle/10635/111919
ISSN: 00219258
DOI: 10.1074/jbc.M212050200
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