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|Title:||Genital human papillomavirus infection among women from major ethnic groups in Singapore.||Authors:||Chow, V.T.
|Issue Date:||Dec-1990||Citation:||Chow, V.T.,Tham, K.M.,Lim-Tan, S.K.,Sng, I.T.,Bernard, H.U. (1990-12). Genital human papillomavirus infection among women from major ethnic groups in Singapore.. Asia-Oceania Journal of Obstetrics and Gynaecology 16 (4) : 373-377. ScholarBank@NUS Repository.||Abstract:||The close epidemiological relationships between specific genital human papillomavirus (HPV) types and neoplasia of the cervix uteri have been extensively documented worldwide, including Singapore. Cervical cancer incidence rates in Singapore show variations between the major ethnic groups. To ascertain the corresponding HPV infection rates among the various races in Singapore, we analysed the cervical smears of 225 women by filter in situ DNA hybridization, and compared the data with a previous similar study. Fourteen (6.2%) individuals were HPV-positive, with HPV 16 and HPV 31 being the commonest types. No significant difference between HPV positivity rates in Chinese (5.0%) and in Malays (6.7%) was found, even though Chinese have a higher cervical cancer incidence than Malays. Furthermore, the cervical HPV carriage rate among women with normal cytology was 5.9%. In the light of reports of high genital HPV prevalence rates detected by DNA amplification, these data support the notion that HPV infection is commonly latent and requires the cooperation of other factors for cervical carcinogenesis.||Source Title:||Asia-Oceania Journal of Obstetrics and Gynaecology||URI:||http://scholarbank.nus.edu.sg/handle/10635/111900||ISSN:||03892328|
|Appears in Collections:||Staff Publications|
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