Please use this identifier to cite or link to this item: https://doi.org/10.1006/cimm.1994.1258
DC FieldValue
dc.titleDifferential effect of Staphylococcal enterotoxin B upon the induction of tolerance on peripheral CD4+Vβ8+ and CD8+Vβ8+ T cells
dc.contributor.authorSabapathy, T.K.
dc.contributor.authorHwang, L.A.
dc.contributor.authorHui, K.M.
dc.date.accessioned2014-11-28T02:50:22Z
dc.date.available2014-11-28T02:50:22Z
dc.date.issued1994
dc.identifier.citationSabapathy, T.K., Hwang, L.A., Hui, K.M. (1994). Differential effect of Staphylococcal enterotoxin B upon the induction of tolerance on peripheral CD4+Vβ8+ and CD8+Vβ8+ T cells. Cellular Immunology 158 (1) : 83-95. ScholarBank@NUS Repository. https://doi.org/10.1006/cimm.1994.1258
dc.identifier.issn00088749
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/111849
dc.description.abstractIt is known that bacterial superantigens can interact with certain VP elements of the T cell receptor to result in the activation, expansion, anergy, and/or deletion of T cells. The induction of peripheral T cell tolerance in AKR/J mice was examined in relation to the amount of staphylococcal enterotoxin B (SEB) administered and it was found that the events leading to the induction of tolerance of Vβ8+ T cells was dependent on the initial dose of superantigen employed. Following administration of a large amount (≥ 10 μg) of SEB into AKR/J mice, expansion of both CD4+Vβ8+ and CD8+Vβ8+ T cells was observed. This initial cell expansion was followed by the decline in the number of CD4+Vβ8+ T cells. The number of CD8+Vβ8+ T cells, however, did not decline and remained high. When a small amount (2 μg) of SEB was employed, it did not stimulate T cell expansion in AKR/J mice. However, when these mice were challenged with SEB, anergy was observed in the CD4+Vβ8+ T cells regardless of the initial dose of SEB. In contrast, the CD8+Vβ8+ T cells were not anergized and were able to proliferate on stimulation with a second dose of SEB. The state of anergy for the CD4+Vβ8+ T cells lasted for at least 70 days, and by 150 days the anergic state was relieved and these CD4+VP8+ T cells were once again able to proliferate in response to SEB. On the other hand, continuous SEB exposure resulted in the decline of both CD4+VP8+ and CD8+Vβ8+ T cells. Although the number of CD4+Vβ8+ and CD8+Vβ8+ T cells apparently returned to normal levels by 150 days, the state of anergy persisted, as demonstrated by the reduction of the response of these T cells following SEB stimulation in vitro. Our data suggest that the initial expansion of T cells is not an absolute prerequisite for the induction of peripheral T cell anergy. Moreover, the continuous presence of superantigen is essential for the deletion and maintenance of a state of anergy for CD8+Vβ+ T cells.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1006/cimm.1994.1258
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentINSTITUTE OF MOLECULAR & CELL BIOLOGY
dc.description.doi10.1006/cimm.1994.1258
dc.description.sourcetitleCellular Immunology
dc.description.volume158
dc.description.issue1
dc.description.page83-95
dc.description.codenCLIMB
dc.identifier.isiutA1994PJ58700006
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