Please use this identifier to cite or link to this item: https://doi.org/10.1074/jbc.271.40.24817
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dc.titleCloning and characterization of islet cell antigen-related protein- tyrosine phosphatase (PTP), a novel receptor-like PTP and autoantigen in insulin-dependent diabetes
dc.contributor.authorCui, L.
dc.contributor.authorYu, W.-P.
dc.contributor.authorDeAizpurua, H.J.
dc.contributor.authorSchmidli, R.S.
dc.contributor.authorPallen, C.J.
dc.date.accessioned2014-11-28T02:50:06Z
dc.date.available2014-11-28T02:50:06Z
dc.date.issued1996
dc.identifier.citationCui, L., Yu, W.-P., DeAizpurua, H.J., Schmidli, R.S., Pallen, C.J. (1996). Cloning and characterization of islet cell antigen-related protein- tyrosine phosphatase (PTP), a novel receptor-like PTP and autoantigen in insulin-dependent diabetes. Journal of Biological Chemistry 271 (40) : 24817-24823. ScholarBank@NUS Repository. https://doi.org/10.1074/jbc.271.40.24817
dc.identifier.issn00219258
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/111825
dc.description.abstractCloning of the cDNA encoding a novel human protein-tyrosine phosphatase (PTP) called islet cell antigen-related PTP (IAR) predicts a receptor-like molecule with an extracellular domain of 614 amino acids containing a hydrophobic signal peptide, one potential N-glycosylation site, and an RGDS peptide which is a possible adhesive recognition sequence. The 376-amino acid intracellular region contains a single catalytic domain. Recombinant IAR polypeptide has phosphatase activity. Northern blot analysis shows tissue- specific expression of two IAR transcripts of 5.5 and 3.7 kilobases, which are most abundant in brain and pancreas. The IAR PTP is homologous in its intracellular region to IA-2, a putative PTP that is an insulin-dependent diabetes mellitus (IDDM) autoantigen. IAR is also reactive with IDDM patient sera. IAR and IA-2 may distinguish different populations of IDDM autoantibodies since they identify overlapping but nonidentical sets of IDDM patients. Thus IAR is likely to be an islet cell antigen useful in the preclinical screening of individuals for risk of IDDM.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1074/jbc.271.40.24817
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentINSTITUTE OF MOLECULAR & CELL BIOLOGY
dc.description.doi10.1074/jbc.271.40.24817
dc.description.sourcetitleJournal of Biological Chemistry
dc.description.volume271
dc.description.issue40
dc.description.page24817-24823
dc.description.codenJBCHA
dc.identifier.isiutA1996VM67400077
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