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https://doi.org/10.1038/sj.cdd.4401946
Title: | c-Jun promotes cellular survival by suppression of PTEN | Authors: | Hettinger, K. Vikhanskaya, F. Poh, M.K. Lee, M.K. de Belle, I. Zhang, J.-T. Reddy, S.A.G. Sabapathy, K. |
Issue Date: | Feb-2007 | Citation: | Hettinger, K., Vikhanskaya, F., Poh, M.K., Lee, M.K., de Belle, I., Zhang, J.-T., Reddy, S.A.G., Sabapathy, K. (2007-02). c-Jun promotes cellular survival by suppression of PTEN. Cell Death and Differentiation 14 (2) : 218-229. ScholarBank@NUS Repository. https://doi.org/10.1038/sj.cdd.4401946 | Abstract: | Activation of c-Jun, a component of the AP-1 family of transcription factors, leads to either promotion or prevention of apoptosis. However, the molecular determinants of c-Jun-mediated cell survival are still unclear. We show here that inducible expression of c-Jun promotes cellular survival by negatively regulating the expression of the tumor-suppressor PTEN, resulting in the concomitant activation of the Akt survival pathway. Consistently, c-jun-/- fibroblasts, which are sensitive to nutrient deprivation, and human cell lines in which c-Jun expression is silenced, express elevated levels of PTEN. siRNA-mediated silencing of PTEN resulted in the reduction of cell-death owing to c-Jun deficiency. c-Jun was found to suppress PTEN expression by binding to a variant AP-1 site found in the 5′ upstream sequences of PTEN promoter. Finally, an inverse correlation between c-Jun and PTEN levels was apparent in a panel of human tumor cell lines, independent of their p53 status. Together, the data demonstrate that c-Jun contributes to the promotion of cellular survival by regulating the expression of PTEN. | Source Title: | Cell Death and Differentiation | URI: | http://scholarbank.nus.edu.sg/handle/10635/111822 | ISSN: | 13509047 | DOI: | 10.1038/sj.cdd.4401946 |
Appears in Collections: | Staff Publications |
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