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Title: Active constituents against HIV-1 protease from Garcinia mangostana
Authors: Chen, S.-X. 
Wan, M.
Loh, B.-N.
Issue Date: 1996
Citation: Chen, S.-X.,Wan, M.,Loh, B.-N. (1996). Active constituents against HIV-1 protease from Garcinia mangostana. Planta Medica 62 (4) : 381-382. ScholarBank@NUS Repository.
Abstract: The ethanol extract of Garcinia mangostana L. (Guttiferae) showed potent inhibitory activity against HIV-1 protease. The activity-guided purification of the extract resulted in the isolation of two active, known compounds. The chemical structures of the isolated compounds were established by spectroscopic analyses as mangostin (IC50 = 5.12 ± 0.41 μM) and γ-mangostin (IC50 = 4.81 ± 0.32 μM). The type of inhibition by both compounds is noncompetitive.
Source Title: Planta Medica
ISSN: 00320943
Appears in Collections:Staff Publications

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