Please use this identifier to cite or link to this item:
Title: Cidea is an essential transcriptional coactivator regulating mammary gland secretion of milk lipids
Authors: Wang, W.
Lv, N.
Zhang, S.
Shui, G. 
Qian, H.
Zhang, J.
Chen, Y.
Ye, J.
Xie, Y.
Shen, Y.
Wenk, M.R.
Li, P.
Issue Date: Feb-2012
Citation: Wang, W., Lv, N., Zhang, S., Shui, G., Qian, H., Zhang, J., Chen, Y., Ye, J., Xie, Y., Shen, Y., Wenk, M.R., Li, P. (2012-02). Cidea is an essential transcriptional coactivator regulating mammary gland secretion of milk lipids. Nature Medicine 18 (2) : 235-243. ScholarBank@NUS Repository.
Abstract: Adequate lipid secretion by mammary glands during lactation is essential for the survival of mammalian offspring. However, the mechanism governing this process is poorly understood. Here we show that Cidea is expressed at high levels in lactating mammary glands and its deficiency leads to premature pup death as a result of severely reduced milk lipids. Furthermore, the expression of xanthine oxidoreductase (XOR), an essential factor for milk lipid secretion, is markedly lower in Cidea-deficient mammary glands. Conversely, ectopic Cidea expression induces the expression of XOR and enhances lipid secretion in vivo. Unexpectedly, as Cidea has heretofore been thought of as a cytoplasmic protein, we detected it in the nucleus and found it to physically interact with transcription factor CCAAT/enhancer-binding protein Î 2 (C/EBPβ) in mammary epithelial cells. We also observed that Cidea induces XOR expression by promoting the association of C/EBPβ onto, and the dissociation of HDAC1 from, the promoter of the Xdh gene encoding XOR. Finally, we found that Fsp27, another CIDE family protein, is detected in the nucleus and interacts with C/EBPβ to regulate expression of a subset of C/EBPβ downstream genes in adipocytes. Thus, Cidea acts as a previously unknown transcriptional coactivator of C/EBPβ in mammary glands to control lipid secretion and pup survival. © 2012 Nature America, Inc. All rights reserved.
Source Title: Nature Medicine
ISSN: 10788956
DOI: 10.1038/nm.2614
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.


checked on May 22, 2020


checked on May 22, 2020

Page view(s)

checked on May 23, 2020

Google ScholarTM



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.