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Title: LIN28/LIN28B: An emerging oncogenic driver in cancer stem cells
Authors: Zhou, J. 
Ng, S.-B.
Chng, W.-J.
Keywords: Cancer stem cell (CSC)
microRNA (miRNA)
Tumor initiating cell (TIC)
Issue Date: May-2013
Citation: Zhou, J., Ng, S.-B., Chng, W.-J. (2013-05). LIN28/LIN28B: An emerging oncogenic driver in cancer stem cells. International Journal of Biochemistry and Cell Biology 45 (5) : 973-978. ScholarBank@NUS Repository.
Abstract: LIN28 (LIN28A) is a reprogramming factor and conserved RNA-binding protein. LIN28B is the only homolog of LIN28 in humans, sharing structure and certain function. LIN28/LIN28B has been identified to be overexpressed in a wide range of solid tumors and hematological malignancies. Blockage of let-7 miRNA biogensis and subsequent derepression of let-7 miRNA target genes by LIN28/LIN28B play important roles in cancer progression and metastasis. We will first provide an overview of LIN28/LIN28B gene and protein structures, followed by summary of the studies that showed their aberrant expression in primary human cancers and relevant clinical significance with emphasis on their roles in formation of cancer stem cells. Next, we will highlight the current knowledge of LIN28/LIN28B regulators and molecular mechanisms of LIN28/LIN28B-mediated oncogenesis. The potential medical applications for targeting LIN28/LIN28B will also be discussed in this review. © 2013 Elsevier Ltd.
Source Title: International Journal of Biochemistry and Cell Biology
ISSN: 13572725
DOI: 10.1016/j.biocel.2013.02.006
Appears in Collections:Staff Publications

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