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Title: Generating specificity and diversity in the transcriptional response to hypoxia
Authors: Lendahl, U.
Lee, K.L. 
Yang, H.
Poellinger, L. 
Issue Date: Dec-2009
Citation: Lendahl, U., Lee, K.L., Yang, H., Poellinger, L. (2009-12). Generating specificity and diversity in the transcriptional response to hypoxia. Nature Reviews Genetics 10 (12) : 821-832. ScholarBank@NUS Repository.
Abstract: The sensing of oxygen levels and maintenance of oxygen homeostasis is crucial for cells. The hypoxic-sensitive regulation of gene expression allows information about the oxygen status to be converted into appropriate cellular responses. Although there is a core transcriptional pathway, the signalling cascade can be modified to allow diversity and specificity in the transcriptional output. In this Review, we discuss recent advances in our understanding of the mechanisms and factors that contribute to the observed diversity and specificity. A deeper knowledge about how hypoxic signalling is tuned will further our understanding of the cellular hypoxic response in normal physiology and how it becomes derailed in disease. © 2009 Macmillan Publishers Limited. All rights reserved.
Source Title: Nature Reviews Genetics
ISSN: 14710056
DOI: 10.1038/nrg2665
Appears in Collections:Staff Publications

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