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Title: α-Catenin and vinculin cooperate to promote high E-cadherin-based adhesion strength
Authors: Thomas, W.A.
Boscher, C.
Chu, Y.-S.
Cuvelier, D.
Martinez-Rico, C.
Seddiki, R.
Heysch, J.
Ladoux, B.
Thiery, J.P. 
Mege, R.-M.
Dufour, S.
Issue Date: 15-Feb-2013
Citation: Thomas, W.A., Boscher, C., Chu, Y.-S., Cuvelier, D., Martinez-Rico, C., Seddiki, R., Heysch, J., Ladoux, B., Thiery, J.P., Mege, R.-M., Dufour, S. (2013-02-15). α-Catenin and vinculin cooperate to promote high E-cadherin-based adhesion strength. Journal of Biological Chemistry 288 (7) : 4957-4969. ScholarBank@NUS Repository.
Abstract: Background: Cadherin interactions with catenins are crucial for intercellular adhesion. Results: αE-catenin and vinculin cooperate to promote the time-dependent reinforcement of cadherin-mediated adhesions. Conclusion: aE-catenin and vinculin form a mechanoresponsive link between cadherin and the underlying actin cytoskeleton. Significance: The force-dependent modulation of a-catenin and vinculin recruitment contributes to the development of cadherin adhesion strength.© 2013 by The American Society for Biochemistry and Molecular Biology, Inc.
Source Title: Journal of Biological Chemistry
ISSN: 00219258
DOI: 10.1074/jbc.M112.403774
Appears in Collections:Staff Publications

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