Please use this identifier to cite or link to this item:
https://doi.org/10.1074/jbc.M112.403774
| Title: | α-Catenin and vinculin cooperate to promote high E-cadherin-based adhesion strength | Authors: | Thomas, W.A. Boscher, C. Chu, Y.-S. Cuvelier, D. Martinez-Rico, C. Seddiki, R. Heysch, J. Ladoux, B. Thiery, J.P. Mege, R.-M. Dufour, S. |
Issue Date: | 15-Feb-2013 | Citation: | Thomas, W.A., Boscher, C., Chu, Y.-S., Cuvelier, D., Martinez-Rico, C., Seddiki, R., Heysch, J., Ladoux, B., Thiery, J.P., Mege, R.-M., Dufour, S. (2013-02-15). α-Catenin and vinculin cooperate to promote high E-cadherin-based adhesion strength. Journal of Biological Chemistry 288 (7) : 4957-4969. ScholarBank@NUS Repository. https://doi.org/10.1074/jbc.M112.403774 | Abstract: | Background: Cadherin interactions with catenins are crucial for intercellular adhesion. Results: αE-catenin and vinculin cooperate to promote the time-dependent reinforcement of cadherin-mediated adhesions. Conclusion: aE-catenin and vinculin form a mechanoresponsive link between cadherin and the underlying actin cytoskeleton. Significance: The force-dependent modulation of a-catenin and vinculin recruitment contributes to the development of cadherin adhesion strength.© 2013 by The American Society for Biochemistry and Molecular Biology, Inc. | Source Title: | Journal of Biological Chemistry | URI: | http://scholarbank.nus.edu.sg/handle/10635/110800 | ISSN: | 00219258 | DOI: | 10.1074/jbc.M112.403774 |
| Appears in Collections: | Staff Publications |
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