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Title: Hepatitis B virus reactivation risk varies with different chemotherapy regimens commonly used in solid tumours
Authors: Ling, W.H.Y.
Soe, P.P.
Pang, A.S.L.
Lee, S.-C. 
Issue Date: May-2013
Citation: Ling, W.H.Y., Soe, P.P., Pang, A.S.L., Lee, S.-C. (2013-05). Hepatitis B virus reactivation risk varies with different chemotherapy regimens commonly used in solid tumours. British Journal of Cancer 108 (10) : 1931-1935. ScholarBank@NUS Repository.
Abstract: Background:Hepatitis B virus (HBV) reactivation may occur with chemotherapy and has significant morbidity and mortality. The United States Centre for Disease Control and Prevention recommends pre-chemotherapy hepatitis B screening for all cancer patients, while the American Society of Clinical Oncology finds that there is insufficient evidence currently to support such a recommendation. Apart from anthracyclines, HBV reactivation rates from other commonly used chemotherapy regimens in solid tumours are not well described.Methods:We compared HBV reactivation risk in patients receiving several commonly used chemotherapy regimens for solid tumours associated with different immunosuppression risk at a tertiary cancer centre in an HBV endemic region.Results:A total of 1149 patients were identified, including 434, 196, 245 and 274, respectively, who received doxorubicin-based, oxaliplatin-or irinotecan-based, carboplatin/gemcitabine, and capecitabine chemotherapy. HBV screening rate was 39% overall. Thirty out of 448 (7%) screened patients were HBsAg positive and 28 out of 30 received prophylactic antiviral therapy with no reactivation. Three out of 1149 patients overall (0.3%) developed HBV reactivation, all from the unscreened doxorubicin group (3 out of 214, 1.4%). No unscreened patients (0 out of 487) in the other three treatment groups developed reactivation (P
Source Title: British Journal of Cancer
ISSN: 00070920
DOI: 10.1038/bjc.2013.225
Appears in Collections:Staff Publications

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