Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/110740
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dc.titleGemcitabine and platinum pathway pharmacogenetics in Asian breast cancer patients
dc.contributor.authorWong, A.L.-A.
dc.contributor.authorYap, H.-L.
dc.contributor.authorYeo, W.-L.
dc.contributor.authorSoong, R.
dc.contributor.authorNg, S.-S.
dc.contributor.authorWang, L.-Z.
dc.contributor.authorCordero, M.T.
dc.contributor.authorYong, W.-P.
dc.contributor.authorGoh, B.-C.
dc.contributor.authorLee, S.-C.
dc.date.accessioned2014-11-26T09:59:41Z
dc.date.available2014-11-26T09:59:41Z
dc.date.issued2011-09
dc.identifier.citationWong, A.L.-A.,Yap, H.-L.,Yeo, W.-L.,Soong, R.,Ng, S.-S.,Wang, L.-Z.,Cordero, M.T.,Yong, W.-P.,Goh, B.-C.,Lee, S.-C. (2011-09). Gemcitabine and platinum pathway pharmacogenetics in Asian breast cancer patients. Cancer Genomics and Proteomics 8 (5) : 255-259. ScholarBank@NUS Repository.
dc.identifier.issn11096535
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/110740
dc.description.abstractBackground/Aim: Gemcitabine/carboplatin is efficacious in breast cancer but results in significant hematologic toxicities. We employed a multi-gene approach to identify variants to predict its toxicities. Patients and Methods: Twenty-six gemcitabine and platinum-based DNA repair pathway polymorphisms were correlated with gemcitabine pharmacokinetics, hematologic toxicities, response and survival in 41 Asian breast cancer patients receiving gemcitabine/ carboplatin. Results: The combined effects of solute carrier family (SLC)28A1+1528C>T and thymidylate synthetase (TYMS)+1494del6 significantly influenced hematologic toxicities: 89% of patients who possessed either SLC28A1+1528TT or TYMS+1494ins6/ins6 (n=9) developed grade 4 thrombocytopenia, versus 14% with neither genotype (n=29; p
dc.sourceScopus
dc.subjectBreast cancer
dc.subjectCarboplatin
dc.subjectGemcitabine
dc.subjectGenetic polymorphisms
dc.subjectPharmacogenetics
dc.typeArticle
dc.contributor.departmentCANCER SCIENCE INSTITUTE OF SINGAPORE
dc.description.sourcetitleCancer Genomics and Proteomics
dc.description.volume8
dc.description.issue5
dc.description.page255-259
dc.identifier.isiutNOT_IN_WOS
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