Please use this identifier to cite or link to this item: https://doi.org/10.1038/nature12598
DC FieldValue
dc.titleDNMT1-interacting RNAs block gene-specific DNA methylation
dc.contributor.authorDi Ruscio, A.
dc.contributor.authorEbralidze, A.K.
dc.contributor.authorBenoukraf, T.
dc.contributor.authorAmabile, G.
dc.contributor.authorGoff, L.A.
dc.contributor.authorTerragni, J.
dc.contributor.authorFigueroa, M.E.
dc.contributor.authorDe Figueiredo Pontes, L.L.
dc.contributor.authorAlberich-Jorda, M.
dc.contributor.authorZhang, P.
dc.contributor.authorWu, M.
dc.contributor.authorD'Alò, F.
dc.contributor.authorMelnick, A.
dc.contributor.authorLeone, G.
dc.contributor.authorEbralidze, K.K.
dc.contributor.authorPradhan, S.
dc.contributor.authorRinn, J.L.
dc.contributor.authorTenen, D.G.
dc.date.accessioned2014-11-26T09:59:35Z
dc.date.available2014-11-26T09:59:35Z
dc.date.issued2013
dc.identifier.citationDi Ruscio, A., Ebralidze, A.K., Benoukraf, T., Amabile, G., Goff, L.A., Terragni, J., Figueroa, M.E., De Figueiredo Pontes, L.L., Alberich-Jorda, M., Zhang, P., Wu, M., D'Alò, F., Melnick, A., Leone, G., Ebralidze, K.K., Pradhan, S., Rinn, J.L., Tenen, D.G. (2013). DNMT1-interacting RNAs block gene-specific DNA methylation. Nature 503 (7476) : 371-376. ScholarBank@NUS Repository. https://doi.org/10.1038/nature12598
dc.identifier.issn00280836
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/110732
dc.description.abstractDNA methylation was first described almost a century ago; however, the rules governing its establishment and maintenance remain elusive. Here we present data demonstrating that active transcription regulates levels of genomic methylation. We identify a novel RNA arising from the CEBPA gene locus that is critical in regulating the local DNA methylation profile. This RNA binds to DNMT1 and prevents CEBPA gene locus methylation. Deep sequencing of transcripts associated with DNMT1 combined with genome-scale methylation and expression profiling extend the generality of this finding to numerous gene loci. Collectively, these results delineate the nature of DNMT1-RNA interactions and suggest strategies for gene-selective demethylation of therapeutic targets in human diseases. © 2013 Macmillan Publishers Limited. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1038/nature12598
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentCANCER SCIENCE INSTITUTE OF SINGAPORE
dc.description.doi10.1038/nature12598
dc.description.sourcetitleNature
dc.description.volume503
dc.description.issue7476
dc.description.page371-376
dc.description.codenNATUA
dc.identifier.isiut000327163200035
Appears in Collections:Staff Publications

Show simple item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

347
checked on Nov 26, 2021

WEB OF SCIENCETM
Citations

332
checked on Nov 18, 2021

Page view(s)

205
checked on Nov 18, 2021

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.