Please use this identifier to cite or link to this item: https://doi.org/10.1189/jlb.1010569
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dc.titleBiphasic activity of cd137 ligand-stimulated monocytes on T cell apoptosis and proliferation
dc.contributor.authorShaqireen Kwajah, M.M.
dc.contributor.authorMustafa, N.
dc.contributor.authorHolme, A.L.
dc.contributor.authorPervaiz, S.
dc.contributor.authorSchwarz, H.
dc.date.accessioned2014-11-26T09:59:29Z
dc.date.available2014-11-26T09:59:29Z
dc.date.issued2011-05
dc.identifier.citationShaqireen Kwajah, M.M., Mustafa, N., Holme, A.L., Pervaiz, S., Schwarz, H. (2011-05). Biphasic activity of cd137 ligand-stimulated monocytes on T cell apoptosis and proliferation. Journal of Leukocyte Biology 89 (5) : 707-720. ScholarBank@NUS Repository. https://doi.org/10.1189/jlb.1010569
dc.identifier.issn07415400
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/110723
dc.description.abstractCD137L (4-1BBL) is a member of the TNFSF and is expressed on APCs as a transmembrane protein. Reverse signaling by CD137L in monocytes causes cell activation and differentiation to mature inflammatory DCs that can stimulate T cell proliferation. However, CD137L agonists have also been reported to induce apoptosis in PBMCs. This study aimed at clarifying these seemingly opposing activities. We find that the dying cells within PBMCs are T cells and that this T cell death is dependent on monocytes and correlates with the monocyte:T cell ratio. This CD137L-induced, monocytemediated T cell apoptosis is reminiscent of MDCD, and both are cell contact-dependent. T cell death is not mediated by CD95 or DR4 or -5 but by ROS produced by the T cells. T cell apoptosis is restricted to the first 24 h of stimulation, and at later time-points, the monocytes differentiate to inflammatory DCs under the influence of CD137L signaling and acquire the capacity to stimulate T cell proliferation from Day 4 onward. This biphasic activity may contribute to infection-induced T cell attrition, where in the early phase (
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1189/jlb.1010569
dc.sourceScopus
dc.subjectCell death
dc.subjectReactive oxygen species
dc.typeArticle
dc.contributor.departmentCANCER SCIENCE INSTITUTE OF SINGAPORE
dc.description.doi10.1189/jlb.1010569
dc.description.sourcetitleJournal of Leukocyte Biology
dc.description.volume89
dc.description.issue5
dc.description.page707-720
dc.description.codenJLBIE
dc.identifier.isiut000290100100009
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