Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.mib.2011.10.007
Title: Plasticity in mast cell responses during bacterial infections
Authors: Chan, C.Y.
St. John, A.L. 
Abraham, S.N.
Issue Date: Feb-2012
Citation: Chan, C.Y., St. John, A.L., Abraham, S.N. (2012-02). Plasticity in mast cell responses during bacterial infections. Current Opinion in Microbiology 15 (1) : 78-84. ScholarBank@NUS Repository. https://doi.org/10.1016/j.mib.2011.10.007
Abstract: Mast cells (MCs) have been implicated in orchestrating the host's early innate immune and adaptive immune responses in several models of acute bacterial infections. Most of this activity results in early clearance of the bacteria and timely resolution of infection. However, during chronic infections because of the prolonged nature of MC-bacterial interactions, the role of the MC in determining the fate of infection is markedly more complex. Depending on the nature of the pathogen, severity of infection, and its association with a preexisting inflammatory disease, MCs may promote rather than contain chronic infections and exacerbate their pathological sequellae. © 2011 Elsevier Ltd.
Source Title: Current Opinion in Microbiology
URI: http://scholarbank.nus.edu.sg/handle/10635/110710
ISSN: 13695274
DOI: 10.1016/j.mib.2011.10.007
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