Please use this identifier to cite or link to this item: https://doi.org/10.1097/ICU.0b013e32832f8040
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dc.titleMyopia genetics: A review of current research and emerging trends
dc.contributor.authorHornbeak, D.M.
dc.contributor.authorYoung, T.L.
dc.date.accessioned2014-11-26T09:06:06Z
dc.date.available2014-11-26T09:06:06Z
dc.date.issued2009-09
dc.identifier.citationHornbeak, D.M., Young, T.L. (2009-09). Myopia genetics: A review of current research and emerging trends. Current Opinion in Ophthalmology 20 (5) : 356-362. ScholarBank@NUS Repository. https://doi.org/10.1097/ICU.0b013e32832f8040
dc.identifier.issn10408738
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/110708
dc.description.abstractPURPOSE OF REVIEW: Myopia, or nearsightedness, is the most common human eye disorder in the world and is a significant global public health concern. Along with cataract, macular degeneration, infectious disease, and vitamin A deficiency, myopia is one of the most important causes of visual impairment worldwide. Severe or high-grade myopia is a leading cause of blindness because of its associated ocular comorbidities of retinal detachment, macular choroidal degeneration, premature cataract, and glaucoma. Ample epidemiologic and molecular genetic studies support heritability of the nonsyndromic forms of this condition. RECENT FINDINGS: Multiple myopia genetic loci have been identified, establishing this entity as a common complex disorder and underscoring the suitability for gene inquiry studies. Animal model research, primarily using form-deprivation techniques, implicates multiple altered regulation of biological substances in the ocular wall layers, which provides important information for prioritizing human candidate gene studies. Recent epidemiologic work supports a greater role for outdoor activity in relieving myopia progression rather than the previous touted young-age near-work activity model. SUMMARY: The identification of myopia susceptibility genes will not only provide insight into the molecular basis of this significant eye disorder, but will also identify pathways involved in eye growth and development. This effort may lead to effective therapies to treat or potentially prevent this common eye condition. © 2009 Lippincott Williams & Wilkins, Inc.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1097/ICU.0b013e32832f8040
dc.sourceScopus
dc.subjectCandidate genes
dc.subjectEpidemiology
dc.subjectGenetics
dc.subjectMapping studies
dc.subjectMyopia
dc.typeReview
dc.contributor.departmentDUKE-NUS GRADUATE MEDICAL SCHOOL S'PORE
dc.description.doi10.1097/ICU.0b013e32832f8040
dc.description.sourcetitleCurrent Opinion in Ophthalmology
dc.description.volume20
dc.description.issue5
dc.description.page356-362
dc.description.codenCOOTE
dc.identifier.isiut000269285800004
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