Please use this identifier to cite or link to this item: https://doi.org/10.1371/journal.pone.0010730
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dc.titleWhat leads indians to participate in clinical trials? A meta-analysis of qualitative studies
dc.contributor.authorShah, J.Y.
dc.contributor.authorPhadtare, A.
dc.contributor.authorRajgor, D.
dc.contributor.authorVaghasia, M.
dc.contributor.authorPradhan, S.
dc.contributor.authorZelko, H.
dc.contributor.authorPietrobon, R.
dc.date.accessioned2014-11-26T09:05:33Z
dc.date.available2014-11-26T09:05:33Z
dc.date.issued2010
dc.identifier.citationShah, J.Y., Phadtare, A., Rajgor, D., Vaghasia, M., Pradhan, S., Zelko, H., Pietrobon, R. (2010). What leads indians to participate in clinical trials? A meta-analysis of qualitative studies. PLoS ONE 5 (5) : -. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0010730
dc.identifier.issn19326203
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/110656
dc.description.abstractBackground: With the globalization of clinical trials, large developing nations have substantially increased their participation in multi-site studies. This participation has raised ethical concerns, among them the fear that local customs, habits and culture are not respected while asking potential participants to take part in study. This knowledge gap is particularly noticeable among Indian subjects, since despite the large number of participants, little is known regarding what factors affect their willingness to participate in clinical trials. Methods: We conducted a meta-analysis of all studies evaluating the factors and barriers, from the perspective of potential Indian participants, contributing to their participation in clinical trials. We searched both international as well as Indianspecific bibliographic databases, including Pubmed, Cochrane, Openjgate, MedInd, Scirus and Medknow, also performing hand searches and communicating with authors to obtain additional references. We enrolled studies dealing exclusively with the participation of Indians in clinical trials. Data extraction was conducted by three researchers, with disagreement being resolved by consensus. Results: Six qualitative studies and one survey were found evaluating the main themes affecting the participation of Indian subjects. Themes included Personal health benefits, Altruism, Trust in physicians, Source of extra income, Detailed knowledge, Methods for motivating participants as factors favoring, while Mistrust on trial organizations, Concerns about efficacy and safety of trials, Psychological reasons, Trial burden, Loss of confidentiality, Dependency issues, Language as the barriers. Conclusion: We identified factors that facilitated and barriers that have negative implications on trial participation decisions in Indian subjects. Due consideration and weightage should be assigned to these factors while planning future trials in India. © 2010 Shah et al.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1371/journal.pone.0010730
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentDUKE-NUS GRADUATE MEDICAL SCHOOL S'PORE
dc.description.doi10.1371/journal.pone.0010730
dc.description.sourcetitlePLoS ONE
dc.description.volume5
dc.description.issue5
dc.description.page-
dc.identifier.isiut000278017300006
dc.published.statePublished
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