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Title: Growth inhibition of pathogenic bacteria by sulfonylurea herbicides
Authors: Kreisberg, J.F.
Ong, N.T.
Krishna, A.
Joseph, T.L.
Wang, J.
Ong, C.
Ooi, H.A.
Sung, J.C.
Siew, C.C.
Chang, G.C.
Biot, F.
Cuccui, J.
Wren, B.W.
Chan, J.
Sivalingam, S.P.
Zhang, L.-H.
Verma, C. 
Tan, P. 
Issue Date: Mar-2013
Citation: Kreisberg, J.F., Ong, N.T., Krishna, A., Joseph, T.L., Wang, J., Ong, C., Ooi, H.A., Sung, J.C., Siew, C.C., Chang, G.C., Biot, F., Cuccui, J., Wren, B.W., Chan, J., Sivalingam, S.P., Zhang, L.-H., Verma, C., Tan, P. (2013-03). Growth inhibition of pathogenic bacteria by sulfonylurea herbicides. Antimicrobial Agents and Chemotherapy 57 (3) : 1513-1517. ScholarBank@NUS Repository.
Abstract: Emerging resistance to current antibiotics raises the need for new microbial drug targets. We show that targeting branchedchain amino acid (BCAA) biosynthesis using sulfonylurea herbicides, which inhibit the BCAA biosynthetic enzyme acetohydroxyacid synthase (AHAS), can exert bacteriostatic effects on several pathogenic bacteria, including Burkholderia pseudomallei, Pseudomonas aeruginosa, and Acinetobacter baumannii. Our results suggest that targeting biosynthetic enzymes like AHAS, which are lacking in humans, could represent a promising antimicrobial drug strategy. Copyright © 2013, American Society for Microbiology.
Source Title: Antimicrobial Agents and Chemotherapy
ISSN: 00664804
DOI: 10.1128/AAC.02327-12
Appears in Collections:Staff Publications

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