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Title: Emergent bursting and synchrony in computer simulations of neuronal cultures
Authors: Maheswaranathan, N.
Ferrari, S.
VanDongen, A.M.J. 
Henriquez, C.S.
Keywords: Bursting
Computer simulations
Neuronal cultures
Small-world networks
Issue Date: 2012
Citation: Maheswaranathan, N., Ferrari, S., VanDongen, A.M.J., Henriquez, C.S. (2012). Emergent bursting and synchrony in computer simulations of neuronal cultures. Frontiers in Computational Neuroscience (MARCH 2012) : 1-9. ScholarBank@NUS Repository.
Abstract: Experimental studies of neuronal cultures have revealed a wide variety of spiking network activity ranging from sparse, asynchronous firing to distinct, network-wide synchronous bursting. However, the functional mechanisms driving these observed firing patterns are not well understood. In this work, we develop an in silico network of cortical neurons based on known features of similar in vitro networks. The activity from these simulations is found to closely mimic experimental data. Furthermore, the strength or degree of network bursting is found to depend on a few parameters: the density of the culture, the type of synaptic connections, and the ratio of excitatory to inhibitory connections. Network bursting gradually becomes more prominent as either the density, the fraction of long range connections, or the fraction of excitatory neurons is increased. Interestingly, biologically prevalent values of parameters result in networks that are at the transition between strong bursting and sparse firing. Using principal components analysis, we show that a large fraction of the variance in firing rates is captured by the first component for bursting networks. These results have implications for understanding how information is encoded at the population level as well as for why certain network parameters are ubiquitous in cortical tissue. © 2012 Maheswaranathan, Ferrari, Vandongen and Henriquez.
Source Title: Frontiers in Computational Neuroscience
ISSN: 16625188
DOI: 10.3389/fncom.2012.00015
Appears in Collections:Staff Publications

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