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|Title:||Chikungunya and dengue fever among hospitalized febrile patients in Northern Tanzania||Authors:||Hertz, J.T.
|Issue Date:||Jan-2012||Citation:||Hertz, J.T., Munishi, O.M., Ooi, E.E., Howe, S., Lim, W.Y., Chow, A., Morrissey, A.B., Bartlett, J.A., Onyango, J.J., Maro, V.P., Kinabo, G.D., Saganda, W., Gubler, D.J., Crump, J.A. (2012-01). Chikungunya and dengue fever among hospitalized febrile patients in Northern Tanzania. American Journal of Tropical Medicine and Hygiene 86 (1) : 171-177. ScholarBank@NUS Repository. https://doi.org/10.4269/ajtmh.2012.11-0393||Abstract:||Consecutive febrile admissions were enrolled at two hospitals in Moshi, Tanzania. Confirmed acute Chikungunya virus (CHIKV), Dengue virus (DENV), and flavivirus infection were defined as a positive polymerase chain reaction (PCR) result. Presumptive acute DENV infection was defined as a positive anti-DENV immunoglobulin M (IgM) enzyme-linked immunsorbent assay (ELISA) result, and prior flavivirus exposure was defined as a positive anti-DENV IgG ELISA result. Among 870 participants, PCR testing was performed on 700 (80.5%). Of these, 55 (7.9%) had confirmed acute CHIKV infection, whereas no participants had confirmed acute DENV or flavivirus infection. Anti- DENV IgM serologic testing was performed for 747 (85.9%) participants, and of these 71 (9.5%) had presumptive acute DENV infection. Anti-DENV IgG serologic testing was performed for 751 (86.3%) participants, and of these 80 (10.7%) had prior flavivirus exposure. CHIKV infection was more common among infants and children than adults and adolescents (odds ratio [OR] 1.9, P = 0.026) and among HIV-infected patients with severe immunosuppression (OR 10.5, P = 0.007). CHIKV infection is an important but unrecognized cause of febrile illness in northern Tanzania. DENV or other closely related flaviviruses are likely also circulating. Copyright © 2012 by The American Society of Tropical Medicine and Hygiene.||Source Title:||American Journal of Tropical Medicine and Hygiene||URI:||http://scholarbank.nus.edu.sg/handle/10635/110502||ISSN:||00029637||DOI:||10.4269/ajtmh.2012.11-0393|
|Appears in Collections:||Staff Publications|
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