Please use this identifier to cite or link to this item:
|Title:||Ceramides and glucosylceramides are independent antagonists of insulin signaling||Authors:||Chavez, J.A.
|Issue Date:||10-Jan-2014||Citation:||Chavez, J.A., Siddique, M.M., Wang, S.T., Ching, J., Shayman, J.A., Summers, S.A. (2014-01-10). Ceramides and glucosylceramides are independent antagonists of insulin signaling. Journal of Biological Chemistry 289 (2) : 723-734. ScholarBank@NUS Repository. https://doi.org/10.1074/jbc.M113.522847||Abstract:||Background: Both ceramides and glucosylceramides have been implicated in the pathogenesis of insulin resistance. Results: These two classes of sphingolipids modulate insulin action but differ by both tissue specificity and mechanism of action. Conclusion: Ceramides and glucosylceramides are independent and separable antagonists of insulin signaling. Significance: These observations will contribute to our understanding of how sphingolipids contribute to obesity-related metabolic diseases. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.||Source Title:||Journal of Biological Chemistry||URI:||http://scholarbank.nus.edu.sg/handle/10635/110500||ISSN:||00219258||DOI:||10.1074/jbc.M113.522847|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Jan 14, 2020
WEB OF SCIENCETM
checked on Jan 7, 2020
checked on Jan 18, 2020
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.