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|Title:||Adoptive T-cell transfer and chemotherapy in the first-line treatment of metastatic and/or locally recurrent nasopharyngeal carcinoma||Authors:||Chia, W.-K.
|Issue Date:||Jan-2014||Citation:||Chia, W.-K., Teo, M., Wang, W.-W., Lee, B., Ang, S.-F., Tai, W.-M., Chee, C.-L., Ng, J., Kan, R., Lim, W.-T., Tan, S.-H., Ong, W.-S., Cheung, Y.-B., Tan, E.-H., Connolly, J.E., Gottschalk, S., Toh, H.-C. (2014-01). Adoptive T-cell transfer and chemotherapy in the first-line treatment of metastatic and/or locally recurrent nasopharyngeal carcinoma. Molecular Therapy 22 (1) : 132-139. ScholarBank@NUS Repository. https://doi.org/10.1038/mt.2013.242||Abstract:||The outcomes for patients with metastatic or locally recurrent Epstein-Barr virus (EBV)-positive nasopharyngeal carcinoma (NPC) remain poor. Adoptive immunotherapy with EBV-specific cytotoxic T lymphocytes (EBV-CTLs) has proven clinical efficacy, but it has never been evaluated in the first-line treatment setting in combination with chemotherapy. To evaluate the safety and efficacy of a chemotherapy in combination with adoptive EBV-CTL transfer, we conducted a phase 2 clinical trial consisting of four cycles of gemcitabine and carboplatin (GC) followed by up to six doses of EBV-CTL. Thirty-eight patients were enrolled, and 35 received GC and EBV-CTL. GC-CTL therapy resulted in a response rate of 71.4% with 3 complete responses and 22 partial responses. With a median follow up of 29.9 months, the 2-year and 3-year overall survival (OS) rate was 62.9 and 37.1%, respectively. Five patients did not require further chemotherapy for more than 34 months since initiation of CTL. Infusion of CTL products containing T cells specific for LMP2 positively correlated with OS (hazard ratio: 0.35; 95% confidence interval: 0.14-0.84; P = 0.014). Our study achieved one of the best survival outcomes in patients with advanced NPC, setting the stage for a future randomized study of chemotherapy with and without EBV-CTL. © The American Society of Gene & Cell Therapy.||Source Title:||Molecular Therapy||URI:||http://scholarbank.nus.edu.sg/handle/10635/110486||ISSN:||15250016||DOI:||10.1038/mt.2013.242|
|Appears in Collections:||Staff Publications|
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