Please use this identifier to cite or link to this item: https://doi.org/10.1634/theoncologist.2012-0124
DC FieldValue
dc.titleUterine leiomyosarcoma in asian patients: Validation of the revised federation of gynecology and obstetrics staging system and identification of prognostic classifiers
dc.contributor.authorTan, P.-S.
dc.contributor.authorKoh, E.
dc.contributor.authorPang, C.
dc.contributor.authorOng, W.-S.
dc.contributor.authorNgo, L.
dc.contributor.authorSoh, L.-T.
dc.contributor.authorQuek, R.
dc.contributor.authorChay, W.-Y.
dc.contributor.authorHo, T.-H.
dc.contributor.authorTay, S.-K.
dc.contributor.authorChew, S.-H.
dc.contributor.authorLim-Tan, S.-K.
dc.contributor.authorKhoo-Tan, H.
dc.contributor.authorLim, S.L.
dc.contributor.authorBusmanis, I.
dc.contributor.authorGoh, L.K.
dc.contributor.authorChia, Y.-N.
dc.contributor.authorChia, W.-K.
dc.contributor.authorLim, T.
dc.date.accessioned2014-11-26T08:32:33Z
dc.date.available2014-11-26T08:32:33Z
dc.date.issued2012
dc.identifier.citationTan, P.-S., Koh, E., Pang, C., Ong, W.-S., Ngo, L., Soh, L.-T., Quek, R., Chay, W.-Y., Ho, T.-H., Tay, S.-K., Chew, S.-H., Lim-Tan, S.-K., Khoo-Tan, H., Lim, S.L., Busmanis, I., Goh, L.K., Chia, Y.-N., Chia, W.-K., Lim, T. (2012). Uterine leiomyosarcoma in asian patients: Validation of the revised federation of gynecology and obstetrics staging system and identification of prognostic classifiers. Oncologist 17 (10) : 1286-1293. ScholarBank@NUS Repository. https://doi.org/10.1634/theoncologist.2012-0124
dc.identifier.issn10837159
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/110460
dc.description.abstractBackground. In 2008, the Federation of Gynecology and Obstetrics (FIGO) revised their 1988 staging system for uterine leiomyosarcomas. In this article, we compare performance of the 2008 and 1988 FIGO systems. Methods. Individual case data were manually culled. Staging was retrospectively assessed according to revised and 1998 FIGO criteria. Overall survival distribution was assessed by the Kaplan-Meier method. Harrell's concordance index was used to assess the discriminative ability of a fitted Cox model to predict overall survival. Results. A total of 110 cases of uterine leiomyosarcomas were reviewed and data from 88 patients were analyzed. In all, 71% of cases were classified as stage I, 7% as stage II, 3% as stage III, and 19% as stage IV under the revised FIGO staging system. Nine patients (10.2%) were downstaged and none were upstaged. The revised FIGO system did not show a significant improvement over the 1988 FIGO system in the ability to discriminate the risk of death of patients between stages, with concordance indexes of 0.70 and 0.71, respectively. Most patients were classified as stage I with age, tumor grade, tumor size, and lymphovascular invasion as prognostic factors. Conclusion. The 2008 revised FIGO staging system for uterine leiomyosarcomas does not perform better than the 1988 system for uterine endometrial carcinomas. A better staging system is needed for these cases. © AlphaMed Press.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1634/theoncologist.2012-0124
dc.sourceScopus
dc.subjectAJCC
dc.subjectFIGO
dc.subjectLeiomyosarcoma
dc.subjectPrognostic
dc.subjectStaging
dc.subjectUterus
dc.typeReview
dc.contributor.departmentDUKE-NUS GRADUATE MEDICAL SCHOOL S'PORE
dc.description.doi10.1634/theoncologist.2012-0124
dc.description.sourcetitleOncologist
dc.description.volume17
dc.description.issue10
dc.description.page1286-1293
dc.description.codenOCOLF
dc.identifier.isiut000310500600011
Appears in Collections:Staff Publications

Show simple item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

5
checked on Nov 29, 2021

WEB OF SCIENCETM
Citations

4
checked on Nov 29, 2021

Page view(s)

142
checked on Nov 18, 2021

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.