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Title: Synthetic mast-cell granules as adjuvants to promote and polarize immunity in lymph nodes
Authors: John, A.L.S. 
Chan, C.Y.
Staats, H.F.
Leong, K.W.
Abraham, S.N.
Issue Date: Mar-2012
Citation: John, A.L.S., Chan, C.Y., Staats, H.F., Leong, K.W., Abraham, S.N. (2012-03). Synthetic mast-cell granules as adjuvants to promote and polarize immunity in lymph nodes. Nature Materials 11 (3) : 250-257. ScholarBank@NUS Repository.
Abstract: Granules of mast cells (MCs) enhance adaptive immunity when, on activation, they are released as stable particles. Here we show that submicrometre particles modelled after MC granules augment immunity when used as adjuvants in vaccines. The synthetic particles, which consist of a carbohydrate backbone with encapsulated inflammatory mediators such as tumour necrosis factor, replicate attributes of MCs in vivo including the targeting of draining lymph nodes and the timed release of the encapsulated mediators. When used as an adjuvant during vaccination of mice with haemagglutinin from the influenza virus, the particles enhanced adaptive immune responses and increased survival of mice on lethal challenge. Furthermore, differential loading of the particles with the cytokine IL-12 directed the character of the response towards Th1 lymphocytes. The synthetic MC adjuvants replicate and enhance the functions of MCs during vaccination, and can be extended to polarize the resulting immunity. © 2012 Macmillan Publishers Limited. All rights reserved.
Source Title: Nature Materials
ISSN: 14761122
DOI: 10.1038/nmat3222
Appears in Collections:Staff Publications

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