Please use this identifier to cite or link to this item: https://doi.org/10.1182/blood-2011-07-358432
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dc.titleMast cell modulation of the vascular and lymphatic endothelium
dc.contributor.authorKunder, C.A.
dc.contributor.authorSt John, A.L.
dc.contributor.authorAbraham, S.N.
dc.date.accessioned2014-11-26T08:32:14Z
dc.date.available2014-11-26T08:32:14Z
dc.date.issued2011-11-17
dc.identifier.citationKunder, C.A., St John, A.L., Abraham, S.N. (2011-11-17). Mast cell modulation of the vascular and lymphatic endothelium. Blood 118 (20) : 5383-5393. ScholarBank@NUS Repository. https://doi.org/10.1182/blood-2011-07-358432
dc.identifier.issn00064971
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/110435
dc.description.abstractMast cells (MCs) promote a wide range of localized and systemic inflammatory responses. Their involvement in immediate as well as chronic inflammatory reactions at both local and distal sites points to an extraordinarily powerful immunoregulatory capacity with spatial and temporal versatility. MCs are preferentially found in close proximity to both vascular and lymphatic vessels. On activation, they undergo a biphasic secretory response involving the rapid release of prestored vasoactive mediators followed by de novo synthesized products. Many actions of MCs are related to their capacity to regulate vascular flow and permeability and to the recruitment of various inflammatory cells from the vasculature into inflammatory sites. These mediators often work in an additive fashion and achieve their inflammatory effects locally by directly acting on the vascular and lymphatic endothelia, but they also can affect distal sites. Along these lines, the lymphatic and endothelial vasculatures of the host act as a conduit for the dissemination of MC signals during inflammation. The central role of the MC-endothelial cell axis to immune homeostasis is emphasized by the fact that some of the most effective current treatments for inflammatory disorders are directed at interfering with this interaction. © 2011 by The American Society of Hematology.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1182/blood-2011-07-358432
dc.sourceScopus
dc.typeReview
dc.contributor.departmentDUKE-NUS GRADUATE MEDICAL SCHOOL S'PORE
dc.description.doi10.1182/blood-2011-07-358432
dc.description.sourcetitleBlood
dc.description.volume118
dc.description.issue20
dc.description.page5383-5393
dc.description.codenBLOOA
dc.identifier.isiut000297265400007
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