Please use this identifier to cite or link to this item:
Title: Genomics and genetics of human and primate y chromosomes
Authors: Hughes, J.F.
Rozen, S. 
Keywords: ampliconic
clonal transmission
Issue Date: Sep-2012
Citation: Hughes, J.F., Rozen, S. (2012-09). Genomics and genetics of human and primate y chromosomes. Annual Review of Genomics and Human Genetics 13 : 83-108. ScholarBank@NUS Repository.
Abstract: In mammals, the Y chromosome plays the pivotal role in male sex determination and is essential for normal sperm production. Yet only three Y chromosomes have been completely sequenced to date-those of human, chimpanzee, and rhesus macaque. While Y chromosomes are notoriously difficult to sequence owing to their highly repetitive genomic landscapes, these dedicated sequencing efforts have generated tremendous yields in medical, biological, and evolutionary insight. Knowledge of the complex structural organization of the human Y chromosome and a complete catalog of its gene content have provided a deeper understanding of the mechanisms that generate disease-causing mutations and large-scale rearrangements. Variation among human Y-chromosome sequences has been an invaluable tool for understanding relationships among human populations. Comprehensive comparisons of the human Y-chromosome sequence with those of other primates have illuminated aspects of Y-chromosome evolutionary dynamics over much longer timescales (>25 million years compared with 100,000 years). The future sequencing of additional Y chromosomes will provide a basis for a more comprehensive understanding of the evolution of Y chromosomes and their roles in reproductive biology. © 2012 by Annual Reviews. All rights reserved.
Source Title: Annual Review of Genomics and Human Genetics
ISSN: 15278204
DOI: 10.1146/annurev-genom-090711-163855
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

Google ScholarTM



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.